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Interleukin-1 beta (IL-1β), Human(CHO-expressed)



Synonyms Catabolin, Interleukin-1 beta, IL1F2
Description Interleukin 1 beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.
Species Human
Source CHO
Specific Activity ED50< 10 pg/ml, measured in a cell proliferation assay using D10S cells, corresponding to a specific activity of >1 x 108 units/mg.
Sequence
APVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVAL
GLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNW
YISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

Measured Molecular Weight 17kDa, observed by non-reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level <0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Interleukin 1 beta (IL-1 beta) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhIL-1β should be stable up to 1 week at 4°C or up to 2 months at -20°C.





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产品编号: Z02978
规格
价格
数量
1 mg ¥14000
10 ug ¥700
50 ug ¥1500