PDX模型

来源于患者原代肿瘤组织的肿瘤移植模型(Patient-derived xenograft模型,PDX模型)为临床前药效的评估以及生物标志物的鉴定提供了有效的研发资源。与使用细胞系建立的肿瘤模型相比,PDX模型减少了体外培养步骤,保持临床肿瘤细胞的形态和分子生物学特征,因而用该模型做出的药效结果将更为准确,与临床试验结果更为接近。金斯瑞拥有多种PDX模型并拥有数十株人原代肿瘤细胞系。


  • Tumor Model Progress
  • Passages
  • Case Study
  • Genotyping Analysis

Major Tumor Types Other Tumor Types
Liver cancer
Bladder cancer, Breast cancer
Lung cancer 
Uterine cancer, Pancreatic cancer

Kidney cancer

Small intestine cancer
Gastric cancer
Ovarian cancer, Gallbladder cancer 
Colorectal cancer
Head and neck cancer
Esophageal cancer
Thyroid cancer
Brain cancer
Mediastinal tumor, etc


Figure1. Human primary tumor model establishment (gastric cancer). The tumors from the sequential passages (from P0 stage to P3 stage) show identical histopathological characteristics.



Figure1. Patient-derived human primary tumor model of lung cancer shows the anti-cancer effects of Sutent on tumor growth and tumor weight.



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