PDX模型
来源于患者原代肿瘤组织的肿瘤移植模型（Patient-derived xenograft模型，PDX模型）为临床前药效的评估以及生物标志物的鉴定提供了有效的研发资源。与使用细胞系建立的肿瘤模型相比，PDX模型减少了体外培养步骤，保持临床肿瘤细胞的形态和分子生物学特征，因而用该模型做出的药效结果将更为准确，与临床试验结果更为接近。金斯瑞拥有多种PDX模型并拥有数十株人原代肿瘤细胞系。
- Tumor Model Progress
- Passages
- Case Study
- Genotyping Analysis
| Major Tumor Types |
Other Tumor Types | Liver cancer | Bladder cancer, Breast cancer | Lung cancer | Uterine cancer, Pancreatic cancer | Kidney cancer | Small intestine cancer | Gastric cancer | Ovarian cancer, Gallbladder cancer | Colorectal cancer | Head and neck cancer | Esophageal cancer | Thyroid cancer | Brain cancer | Mediastinal tumor, etc | |
 Figure1. Human primary tumor model establishment (gastric cancer). The tumors from the sequential passages (from P0 stage to P3 stage) show identical histopathological characteristics. |
 Figure1. Patient-derived human primary tumor model of lung cancer shows the anti-cancer effects of Sutent on tumor growth and tumor weight. |
 Table. The table shows genotyping analysis for K-ras, B-raf, EGFR, and PIK3CA in patient-derived human primary tumor model. |
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