G蛋白偶联受体是受体蛋白家族中最大的成员之一,在细胞信号转导过程中发挥重要生物学功能,是最重要的药物靶点。金斯瑞团队历经8年多时间,开发了170种以上具有知识产权的GPCR稳定细胞株。这些细胞株均通过功能性和稳定性验证,以满足客户的GPCR药物活性筛选与评价需求。

服务内容

  • 化合物活性筛选与评价(基于钙流、cAMP、报告基因或IP-1的检测)
  • 化合物与受体间的亲和力分析(基于放射性同位素)
  • 提供GPCR稳定细胞株构建服务或直接出售细胞株产品

GPCR稳定细胞株

    Family
    Receptor
    Cell Line
    Cat.No.
    5-Hydroxytryptamine receptor 5-HT2A/HTR2A CHO-K1/5-HT2A
    5-HT2B/HTR2B CHO-K1/5-HT2B
    5-HT2B/HTR2B HEK293/5-HT2B
    M00328
    5-HT2C/HTR2C CHO-K1/5-HT2C
    5-HT2C/HTR2C HEK 293/5-HT2C
    HTR4 CHO-K1/5-HT4/Gα15
    HTR7 293/5-HT7/CRE-Luc
    Acetylcholine receptor (muscarinic) M1/CHRM1 CHO-K1/M1
    M2/CHRM2 CHO-K1/M2/Gα15
    M3/CHRM3 CHO-K1/M3
    M4/CHRM4 CHO-K1/M4/Gα15
    M5/CHRM5 CHO-K1/M5
    Adenosine receptor ADORA1 CHO-K1/ADORA1/Gα15
    ADORA1 293/ADORA1/Gα15
    ADORA2a CHO-K1/ADORA2A/Gα15
    Mouse ADORA2a CHO-K1/mouse ADORA2a New
    M00575
    ADORA2B CHO-K1/ADORA2B/Gα15
    ADORA3 CHO-K1/ADORA3/Gqi5
    Adrenoceptors ADRB3 293/ADRB3/CRE-Luc
    ADRA1B CHO-K1/ADRA1B
    ADRA1D CHO-K1/ADRA1D
    ADORA2A CHO-K1/ADRA2A/Gα15
    ADORA2B CHO-K1/ADRA2B/Gqi5
    ADORA2C CHO-K1/ADRA2C/Gα15
    ADORA1 CHO-K1/ADRA1/Gα15
    ADORA2 CHO-K1/Ga15/ADRB2
    ADORA1A CHO-K1/ADRA1A
    Angiotensin receptor AT1 HEK 293/AT1
    AT1 293T/AT1
    Apelin receptor AGTRL1 CHO-K1/AGTRL1/Gα15
    Bile acid receptor GPBAR1 CHO-K1/GPBAR1SatbleCellLine

返回顶部

    Family
    Receptor
    Cell Line
    Cat.No.
    Bombesin receptor BB1 CHO-K1/BB1
    BB2/GRPR CHO-K1/BB2
    BB3/BRS3 CHO-K1/BB3
    Bradykinin receptor B2 CHO-K1/B2/Gα15
    Calcitonin receptor AMY1 CHO-K1/Gα15/AMY1 New
    AMY2 CHO-K1/Gα15/AMY2 New
    AMY3 CHO-K1/Gα15/AMY3 New
    RAMP2/CALCRL CHO-K1/RAMP2
    M00450
    RAMP3/CALCRL CHO-K1/Ga15/RAMP3
    M00479
    CALCR/CT CHO-K1/CT/Gα15
    Calcium-sensing receptor CASR CHO-K1/CASR
    Cannabinoid receptor CNR1/CB1 CHO-K1/CB1/Gα15
    CB2 CHO-K1/CB2
    Chemerin receptor CMKLR1 CHO-K1/CMKLR1/Gα15
    Chemokine receptor CCR1 CHO-K1/Gα15/CCR1 New
    CCR5 CHO-K1/Gα15/CCR5 New
    CXCR1/IL8RA CHO-K1/Gα15/CXCR1 New
    CXCR3 CHO-K1/Gα15/CXCR3 New
    CXCR4 CHO-K1/Gα15/hCXCR4 New
    CXCR5/BLR1 CHO-K1/Gα15/CXCR5 New
    Cholecystokinin receptor CCKA/CCKAR CHO-K1/CCKA/Gα15
    CCKB/CCKBR CHO-K1/CCKB
    Class A orphan GPR68/OGR1 CHO-K1/GPR68/Gα15
    GPR119 CHO-K1/GPR119
    M00499
    GPR68/OGR1 CHO-K1/Ga15/GPR68
    MRGPRD/MRGD CHO-K1/Ga15/MRGPRD
    M00467
    MRGPRX1 CHO-K1/Ga15/MRGPRX1
    M00484
    MRGPRX1 CHO-K1
    M00425
    Complement peptide receptor C5a/C5AR1 CHO-K1/C5a/Gα15
    Corticotropin releasing factor receptor CRF1/CRHR1 CHO-K1/CRF1/Gα15
    CRF2 CHO-K1/CRF2/Gα15
    Dopamine receptor D2 CHO-K1/D2/Gα15
    D1/DRD1 CHO-K1/D1
    M00247
    D2(Short) CHO-K1/D2s/Gα15
    D1/DRD1 CHO-K1/CRE-Luciferase/DRD1
    M00248
    D1/DRD1 HEK293/CRE-Luciferase/DRD1
    M00348
    DRD4 293 c18/DRD4
    M00477
    Endothelin receptor ETA/EDNRA CHO-K1/EDNRA
    ETB/EDNRB CHO-K1/EDNRB
    Formylpeptide receptor FPR1 CHO-K1/FPR1/Gα15
    Free fatty acid receptor FFA2 CHO-K1/FFA2/Gα15
    GPR40/FFA1 CHO-K1/FFA1/Gα15

返回顶部

    Family
    Receptor
    Cell Line
    Cat.No.
    Galanin receptor GAL1/GALR1 CHO-K1/GAL1/Gα15
    GAL2/GALR2 CHO-K1/GAL2
    Glucagon receptor GHRHR 293/GHRH/Gα15
    GLP-1/GLP1R CHO-K1/GLP1/Gα15
    GLP-1/GLP1R HEK293/CRE-luc/GLP1R New
    M00562
    GLP-2/GLP2R CHO-K1/GLP2/Gα15
    GCGR CHO-K1/GCGR/Gα15
    GCGR HEK 293/GCGR/Gα15
    SCTR CHO-K1/SCTR/Gα15
    GIPR CHO-K1/GIPR/Gα15
    Gonadotropin releasing hormone receptor GNRHR CHO-K1/GNRHR/Gα15
    Growth hormone releasing peptides receptor GHSR CHO-K1/GHSR
    Histamine receptor H1/HRH1 293/H1
    H2/HRH2 CHO-K1/H2/Gα15
    H3/HRH3 CHO-K1/H3/Gα15
    H4/HRH4 CHO-K1/H4/Gα15
    Hydroxycarboxlic acid receptor GPR109A CHO-K1/NIACR1/Gα15
    Kisspeptin receptor KiSS1/GPR54 CHO-K1/KiSS1
    Leukotriene receptor FPRL1 CHO-K1/FPRL1/Gα15
    CysLT1 CHO-K1/CysLT1/Gα15
    OXER1/flag CHO-K1/Gα15/OXER1
    M00488
    LTB4R CHO-K1/LTB4/Gα15
    Lysophospholipid receptor EDG3 RH7777/EDG3
    M00476
    CEDG1 CHO-K1/Gα15/EDG1
    M00574
    EDG6/S1P4 McA-RH7777/EDG6
    M00465
    P2Y5/LAPR6 McA-RH7777/P2Y5
    M00472
    EDG4/LAP2 RH7777/EDG4
    Melanin concentrating hormone receptor MCH1/GPR24 293/MCH1
    MCH2/GPR145 CHO-K1/MCH2
    Melanocortin receptor MC1 CHO-K1/MC1
    M00240
    MC2 CHO-K1/MC2/Gα15
    MC3 CHO-K1/MC3/Gα15
    MC3 293/MC3/CRE-Luc
    MC4 CHO-K1/MC4/Gα15
    MC5 CHO-K1/MC5/Gα15
    Melatonin receptor MTNR1A CHO-K1/MT1/Gα15
    MT2/MTNR1B CHO-K1/MT2/Gα15
    Metabropic glutamate receptor mGlu2/GRM2 CHO-K1/GRM2/Gα15
    Motilin receptor MTLR/MLNR CHO-K1/MTLR/Gα15

返回顶部

    Family
    Receptor
    Cell Line
    Cat.No.
    Neuromedin receptor NMU2 293T/NMU2
    NMU1/GPR66 CHO-K1/NMU1
    Neuropeptide S receptor NPS1b CHO-K1/NPS1b/Gα15
    NPSR1 CHO-K1/NPS1a/Gα15
    Neuropeptide Y receptor NPY2 CHO-K1/NPY2/Gqi5
    NPY4R CHO-K1/NPY4/Gα15
    Neurotensin receptor NTS1/NT1 CHO-K1/NTS1
    Neuropeptide FF/neuropeptide AF receptors NPFFR1 CHO-K1/Gα15/NPFFR1
    M00431
    NPFFR2 CHO-K1/Gα15/NPFFR2
    M00474
    Opioid & opioid-like receptor OPRD1 CHO-K1/OPRD1/Gα15
    OPRK1 CHO-K1/OPRK1/Gα15
    OPRM1 CHO-K1/OPRM1/Gα15
    OPRL1 CHO-K1/OPRL1/Gα15
    Orexin receptor OX1 CHO-K1/OX1
    OX2 CHO-K1/OX2
    oxoglutarate receptor GPR99 CHO-K1/Ga15/GPR99
    M00483
    P2Y receptor P2Y1 1321N1/P2Y1
    P2Y2 1321N1/P2Y2
    P2Y4 1321N1/P2Y4
    P2Y6 1321N1/P2Y6
    P2Y11 1321N1/P2Y11
    P2Y12 1321N1/P2Y12/Gα15
    Parathyroid hormone receptor PTH1/PTHR1 CHO-K1/PTH1/Gα15
    PTH1/PTHR2 293/PTH2/CRE-Luc
    Peptide P518 receptor QRFP/GPR103 CHO-K1/GPR103/Gα15
    Platelet activating factor receptor PAFR/PTAFR CHO-K1/PTAFR
    Prolactin releasing peptide receptor PRLHR CHO-K1/PRLHR
    Prostanoid receptor DP2 CHO-K1/DP2/Gα15
    EP1/PTGER1 293/EP1
    EP2/PTGER2 CHO-K1/EP2/Gα15
    EP4 293 c18/EP4
    M00485
    FP/PTGFR 293/FP/Gα15
    IP1/PTGIR CHO-K1/IP1/Gα15
    TP/TBXA2R 293/TP
    PTGDR/DP1 CHO-K1/DP1/Gα15
    Proteinase-activated receptor PAR2 CHO-K1/PAR2/Gα15
    PAR4/F2RL3 CHO-K1/PAR4

返回顶部

    Family
    Receptor
    Cell Line
    Cat.No.
    Somatostatin receptor SST1 CHO-K1/SST1/Gqi5
    SST2/SSTR2 CHO-K1/SST2/Gα15
    SST3 CHO-K1/SST3/Gα15
    SST4/SSTR4 CHO-K1/SST4/Gα15
    SST5/SSTR5 CHO-K1/SST5/Gα15
    Tachykinin receptor NK1/TACR1 CHO-K1/NK1
    NK2/TACR2 CHO-K1/NK2
    NK3/TACR3 CHO-K1/NK3
    Thyrtropin releasing hormone receptor TRH1/TRHR CHO-K1/TRH1
    Urotensin receptor UTR2 CHO-K1/UT2/Gα15
    Vasopressin and oxytocin receptor OT/OXTR CHO-K1/OXTR
    V1B CHO-K1/V1B
    V2 CHO-K1/V2/Gα15
    VIP and PACAP receptor PAC1 CHO-K1/PAC1/Gα15
    VPAC2 CHO-K1/VPAC2/Gα15
    VPAC1/VIP1 CHO-K1/VPAC1/Gα15
    VIPR2 CHO-K1/CRE/Luciferase/VIPR2 New
    Control \ CHO-K1/CRE/Luc
    \ CHO-K1/Gα15
    \ CHO-K1/Gqi5
    \ HEK293/Gα15 New

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