![IL-10, Human(CHO-expressed) IL-10, Human(CHO-expressed)](/product/documents/down?doc_name=Z03121_cell Proliferation Assay.png&file=scm_files/productFile_notes/2024/01/19/4af0ce53-e171-4d07-bc96-c4be8fd07355.png)
ED50 < 2.0 ng/ml, measured in a cell proliferation assay using MC/9 cells.
![IL-10, Human(CHO-expressed) IL-10, Human(CHO-expressed)](/product/documents/down?doc_name=Z03121_SDS-PAGE.png&file=scm_files/productFile_notes/2024/01/19/89db188b-87a3-4489-beff-dfdb3c95cfac.png)
Lane 1: 2 μg of IL-10, Human(CHO-expressed), non-reducing (NR)
Lane 2: 2 μg of IL-10, Human(CHO-expressed), reducing (R)
> 95% as analyzed by SDS-PAGE
IL-10, Human(CHO-expressed)
Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80% sequence homology with Epstein-Barr Virus protein BCRFI. It is produced by many immune cells, such as T-cells, macrophages, mast cells, and dendritic cells. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and Th2 cells. It also displays ability to suppress Antigen-Presenting Cell (APC) function. The net effect of Interleukin-10 appears to be inhibitory; however, stimulatory effects, such as stimulation of B cell maturation and antibody production, are also reported.
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