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Targeted sequencing of cancer-related genes reveals a recurrent TOP2A variant which affects DNA binding and coincides with global transcriptional changes in glioblastoma
Authors: Bartlomiej Gielniewski, Katarzyna Poleszak, Adria-Jaume Roura, Paulina Szadkowska, Karol Jacek, Sylwia K Krol, Rafal Guzik, Paulina Wiechecka, Marta Maleszewska, Beata Kaza, Andrzej Marchel, Tomasz Czernicki, Andrzej Koziarski, Grzegorz Zielinski, Andrzej Styk, Maciej Kawecki, Cezary Szczylik, Ryszard Czepko, Mariusz Banach, Wojciech Kaspera, Wojciech Szopa, Mateusz Bujko, Bartosz Czapski, Miroslaw Zabek, Ewa Iżycka-Świeszewska, Wojciech Kloc, Pawel Nauman, Joanna Cieslewicz, Wieslawa Grajkowska, Natalia Morosini, Houtan Noushmehr, Bartosz Wojtas, Bozena Kaminska
Journal: Int J Cancer
PubMed ID: 37338006
Doi: 10.1002/ijc.34631
Products & Services: Proteins, Expression, Isolation and Analysis   
Virtual screening, identification, and potential antioxidant mechanism of novel bioactive peptides during aging by a short-chain peptidomics, quantitative structure-activity relationship analysis, and molecular docking
Authors: An Du, Wei Jia
Journal: Food Res Int
PubMed ID: 37689894
Doi: 10.1016/j.foodres.2023.113129
Products & Services: Proteins, Expression, Isolation and Analysis   
Identification of paeoniflorin from Paeonia lactiflora pall As an inhibitor of tryptophan 2,3-dioxygenase and assessment of its pharmacological effects on depressive mice
Authors: Xiaoxia Liang, Ting Su, Pingzhou Wu, Yanting Dai, Yanmin Chen, QiQi Wang, Cheng Cao, Fenglian Chen, Qing Wang, Shuling Wang
Journal: J Ethnopharmacol
PubMed ID: 37315645
Doi: 10.1016/j.jep.2023.116714
Products & Services: Proteins, Expression, Isolation and Analysis   
Antibody aggregation can lead to reduced Protein A binding capacity and low step yield
Authors: Gaoya Yuan, Meng Qu, Qi Geng, Wanyuan Dong, Xudong Zhang, Yifeng Li
Journal: Protein Expr Purif
PubMed ID: 37271409
Doi: 10.1016/j.pep.2023.106315
Products & Services: Proteins, Expression, Isolation and Analysis   
Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing
Authors: Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G Mancini, Gavin L Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J Fisher, Annie K Brown, Ramya H Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L Mackall, Steven A Feldman
Journal: Mol Cancer
PubMed ID: 37365642
Doi: 10.1186/s12943-023-01799-7
Products & Services: Proteins, Expression, Isolation and Analysis   
Genome-wide characterization of extrachromosomal circular DNA in gastric cancer and its potential role in carcinogenesis and cancer progression
Authors: Xianming Jiang, Xiaoguang Pan, Wenchao Li, Peng Han, Jiaying Yu, Jing Li, Haoran Zhang, Wei Lv, Ying Zhang, Yulong He, Xi Xiang
Journal: Cell Mol Life Sci
PubMed ID: 37369919
Doi: 10.1007/s00018-023-04838-0
Products & Services: Proteins, Expression, Isolation and Analysis   
ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway
Authors: Songnan Wang, Volker Böhnert, Alby J Joseph, Valentino Sudaryo, Jason Swinderman, Feiqiao B Yu, Xuchao Lyu, Gemini Skariah, Vishvak Subramanyam, Luke A Gilbert, Hani Goodarzi, Li Lingyin
Journal: biorxiv
PubMed ID: 37333273
Doi: 10.1101/2023.06.01.543353
Products & Services: Proteins, Expression, Isolation and Analysis   
CLDN182 and 4-1BB bispecific antibody givastomig exerts antitumor activity through CLDN182-expressing tumor-directed T-cell activation
Authors: Jing Gao, Zhengyi Wang, Wenqing Jiang, Yanni Zhang, Zhen Meng, Yanling Niu, Zhen Sheng, Chan Chen, Xuejun Liu, Xi Chen, Chanjuan Liu, Keren Jia, Cheng Zhang, Haiyan Liao, Jaeho Jung, Eunsil Sung, Hyejin Chung, Jingwu Z Zhang, Andrew X Zhu, Lin Shen
Journal: J Immunother Cancer
PubMed ID: 37364935
Doi: 10.1136/jitc-2023-006704
Products & Services: Proteins, Expression, Isolation and Analysis   
Glutamine synthetase (GS) knockout (KO) using CRISPR/Cpf1 diversely enhances selection efficiency of CHO cells expressing therapeutic antibodies
Authors: Witsanu Srila, Martina Baumann, Markus Riedl, Kuntalee Rangnoi, Nicole Borth, Montarop Yamabhai
Journal: Sci Rep
PubMed ID: 37380701
Doi: 10.1038/s41598-023-37288-6
Products & Services: Proteins, Expression, Isolation and Analysis   
An Inferred Ancestral CotA Laccase with Improved Expression and Kinetic Efficiency
Authors: Lei Lei, Lijun Zhao, Yiqia Hou, Chen Yue, Pulin Liu, Yanli Zheng, Wenfang Peng, Jiangke Yang
Journal: Int J Mol Sci
PubMed ID: 37446078
Doi: 10.3390/ijms241310901
Products & Services: Recombinant Proteins   

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