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Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers
Authors: Seth P Jones, Kali H Cook, Melody L Holmquist, Liam J Almekinder, Annie M Delaney, Ryhl Charles, Natalie Labbe, Janai Perdue, Niaya Jackson, Michael E Pichichero, Ravinder Kaur, Lea V Michel, Michael L Gleghorn
Journal: Proteins
PubMed ID: 36065600
Doi: 10.1002/prot.26418
Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens
Authors: Matheus Oliveira de Souza, Bharat Madan, I-Ting Teng, Aric Huang, Lihong Liu, Ahmed S Fahad, Sheila N Lopez Acevedo, Xiaoli Pan, Mallika Sastry, Matias Gutierrez-Gonzalez, Michael T Yin, Tongqing Zhou, David D Ho, Peter D Kwong, Brandon J DeKosky
Journal: Front Immunol
PubMed ID: 36119018
Doi: 10.3389/fimmu.2022.977064
A recombinant subunit vaccine candidate produced in plants elicits neutralizing antibodies against SARS-CoV-2 variants in macaques
Authors: Narach Khorattanakulchai, Kanjana Srisutthisamphan, Balamurugan Shanmugaraj, Suwimon Manopwisedjaroen, Kaewta Rattanapisit, Chalisa Panapitakkul, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Arunee Thitithanyanont, Anan Jongkaewwattana, Waranyoo Phoolcharoen
Journal: Front Plant Sci
PubMed ID: 36247553
Doi: 10.3389/fpls.2022.901978
A megadiverse naïve library derived from numerous camelids for efficient and rapid development of VHH antibodies
Authors: Meiniang Wang, Likun Wei, Haitao Xiang, Bingzhao Ren, Xiaopan Liu, Lin Jiang, Naibo Yang, Jiahai Shi
Journal: Anal Biochem
PubMed ID: 36108795
Doi: 10.1016/j.ab.2022.114871
Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors
Authors: Hadar Cohen, Noam Baram, Chaya Mushka Fridman, Liat Edry-Botzer, Dor Salomon, Motti Gerlic
Journal: Elife
PubMed ID: 36155655
Doi: 10.7554/eLife.82766
Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy
Authors: Qi Yu , Xuanyunjing Gong , Yue Tong , Min Wang , Kai Duan , Xinyu Zhang , Feng Ge , Xilan Yu , Shanshan Li
Journal: NaCommunt
PubMed ID: 36167807
Doi: 10.1038/s41467-022-33423-5
SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins
Authors: Museer A Lone, Mari J Aaltonen, Aliza Zidell, Helio F Pedro, Jonas A Morales Saute, Shalett Mathew, Payam Mohassel, Carsten G Bönnemann, Eric A Shoubridge, Thorsten Hornemann
Journal: J Clin Invest
PubMed ID: 35900868
Doi: 10.1172/JCI161908
A 1-aminocyclopropane-1-carboxylic-acid (ACC) dipeptide elicits ethylene responses through ACC-oxidase mediated substrate promiscuity
Authors: John Vaughan-Hirsch, Dongdong Li, Albert Roig Martinez, Stijn Roden, Jolien Pattyn, Shu Taira, Hitomi Shikano, Yoko Miyama, Yukari Okano, Arnout Voet, Bram Van de Poel
Journal: Front Plant Sci
PubMed ID: 36172554
Doi: 10.3389/fpls.2022.995073
Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma
Authors: Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, Wenshu Tang, Liang Duan, Ying Wang, Eleanor McCabe, Mengying Hu, Zhuo Yu, Hanzhuang Liu, Chung Hang Jonathan Choi, Joseph Jao-Yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-Lok Cheng
Journal: Mol Ther
PubMed ID: 36146933
Doi: 10.1016/j.ymthe.2022.09.012
Exploring the Binding Affinity and Mechanism between ACE2 and the Trimers of Delta and Omicron Spike Proteins by Molecular Dynamics Simulation and Bioassay
Authors: Liping Zhou, Tingting Liu, Mengxia Mo, Yulong Shi, Leyun Wu, Yishui Li, Qiuping Qin, Weiliang Zhu, Chengkun Wu, Likun Gong, Zhijian Xu
Journal: J Chem Inf Model
PubMed ID: 36053674
Doi: 10.1021/acs.jcim.2c00881

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