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Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity
Authors: Seounghun Kang, Aslan Mansurov, Trevin Kurtanich, Hye Rin Chun, Anna J Slezak, Lisa R Volpatti, Kevin Chang, Thomas Wang, Aaron T Alpar, Kirsten C Refvik, O Isabella Hansen, Gustavo J Borjas, Ha-Na Shim, Kevin T Hultgren, Suzana Gomes, Ani Solanki, Jun Ishihara, Melody A Swartz, Jeffrey A Hubbell
Journal: Sci Adv
PubMed ID: 38019919
Doi: 10.1126/sciadv.adh9879
Jianpi Huayu Decoction suppresses cellular senescence in colorectal cancer via p53-p21-Rb pathway: Network pharmacology and in vivo validation
Authors: Shiting Wang, Ying Xing, Ruiping Wang, Zhichao Jin
Journal: J Ethnopharmacol
PubMed ID: 37931831
Doi: 10.1016/j.jep.2023.117347
Products & Services: Molecular Biology Reagents   
Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal
Authors: Max Pearson, Carl Haslam, Andrew Fosberry, Emma J Jones, Mark Reglinski, Lucy Reeves, Robert J Edwards, Richard Ashley Lawrenson, Jonathan C Brown, Danuta Mossakowska, James Edward Pease, Shiranee Sriskandan
Journal: Sci Rep
PubMed ID: 37923786
Doi: 10.1038/s41598-023-46036-9
Products & Services: Molecular Biology Reagents   
Safety and efficacy of the intranasal spray SARS-CoV-2 vaccine dNS1-RBD: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
Authors: Fengcai Zhu, Shoujie Huang, Xiaohui Liu, Qi Chen, Chunlan Zhuang, Hui Zhao, Jinle Han, Anjuli May Jaen, Thai Hung Do, Jonathan Grant Peter, Alexander Gonzalez Dorado, Louie S Tirador, Gelza Mae A Zabat, Ralph Elvi M Villalobos, Gemalyn Pineda Gueco, Lauren Livia Greta Botha, Shirley Patricia Iglesias Pertuz, Jiaxiang Tan, Kongxin Zhu, Jiali Quan, Hongyan Lin, Yue Huang, Jizong Jia, Xiafei Chu, Junyu Chen, Yixin Chen, Tianying Zhang, Yingying Su, Changgui Li, Xiangzhong Ye, Ting Wu, Jun Zhang, Ningshao Xia
Journal: Lancet Respir Med
PubMed ID: 37979588
Doi: 10.1016/S2213-2600(23)00349-1
Products & Services: Molecular Biology Reagents   
Experimental co-infection of calves with SARS-CoV-2 Delta and Omicron variants of concern
Authors: Konner Cool, Natasha N Gaudreault, Jessie D Trujillo, Igor Morozov, Chester D McDowell, Dashzeveg Bold, Taeyong Kwon, Velmurugan Balaraman, Patricia Assato, Daniel W Madden, Emily Mantlo, Jayme Souza-Neto, Franco Matias-Ferreyra, Jaime Retallick, Gagandeep Singh, Michael Schotsaert, Mariano Carossino, Udeni B R Balasuriya, William C Wilson, Roman M Pogranichniy, Adolfo García-Sastre, Juergen A Richt
Journal: Emerg Microbes Infect
PubMed ID: 37938158
Doi: 10.1080/22221751.2023.2281356
Products & Services: Molecular Biology Reagents   
RAGE Is a Receptor for SARS-CoV-2 N Protein and Mediates N Protein-induced Acute Lung Injury
Authors: Jie Xia, Jiangmei Wang, Liyang Ying, Ruoqiong Huang, Kai Zhang, Ruoyang Zhang, Wenqi Tang, Qi Xu, Dengming Lai, Yan Zhang, Yaoqin Hu, Xiaodie Zhang, Ruoxi Zang, Jiajie Fan, Qiang Shu, Jianguo Xu
Journal: Am J Respir Cell Mol Biol
PubMed ID: 37478333
Doi: 10.1165/rcmb.2022-0351OC
Products & Services: Recombinant Proteins   
ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells
Authors: Meng Bian, Shan Li, Hanzong Zhou, Lijun Bi, Yong Shen, Chen Tingjin, Xinbing Yu, Yan Huang, Qingxia Xu
Journal: PLoS Negl Trop Dis
PubMed ID: 37948465
Doi: 10.1371/journal.pntd.0011727
Products & Services: Gene Synthesis   
Molecular basis for the catalytic mechanism of human neutral sphingomyelinases 1 (hSMPD2)
Authors: Jingbo Yi, Boya Qi, Jian Yin, Ruochong Li, Xudong Chen, Junhan Hu, Guohui Li, Sensen Zhang, Yuebin Zhang, Maojun Yang
Journal: Nat Commun
PubMed ID: 38012235
Doi: 10.1038/s41467-023-43580-w
Structure-directed bioengineering the lid1 of cold-adapted Pseudomonas sp TB11 esterase to boost catalytic capacity
Authors: Linlin Sha, Wen-Sen He, Tian Zheng, Yang Fei, Yu Fang, Huqing Yang, Gang Chen
Journal: Int J Biol Macromol
PubMed ID: 37992944
Doi: 10.1016/j.ijbiomac.2023.128302
Products & Services: Gene Synthesis   
MiR126-targeted-nanoparticles combined with PI3K/AKT inhibitor as a new strategy to overcome melanoma resistance
Authors: Maria Beatrice Arasi, Gabriele De Luca, Laura Chronopoulou, Francesca Pedini, Eleonora Petrucci, Michela Flego, Annarita Stringaro, Marisa Colone, Luca Pasquini, Massimo Spada, Valentina Lulli, Maria Chiara Perrotta, George Adrian Calin, Cleofe Palocci, Mauro Biffoni, Federica Felicetti, Nadia Felli
Journal: Mol Ther
PubMed ID: 37990493
Doi: 10.1016/j.ymthe.2023.11.021
Products & Services: Molecular Biology Reagents   

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