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Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif
Authors: Wuyang Shi , Shibo Sun , Haowen Liu , Yao Meng , Kangshuai Ren , Guoying Wang , Minghui Liu , Jiaqi Wu , Yue Zhang , Huang Huang , Meiyun Shi , Weiping Xu , Qiang Ma , Bingbing Sun , Jianqiang Xu
Journal: Redox biology
Doi: 10.1016/j.redox.2024.103050
Products & Services: Proteins, Expression, Isolation and Analysis   
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines
Authors: Gisele Nishiguchi , Lauren G Mascibroda , Sarah M Young , Elizabeth A Caine , Sherif Abdelhamed , Jeffrey J Kooijman , Darcie J Miller , Sourav Das , Kevin McGowan , Anand Mayasundari , Zhe Shi , Juan M Barajas , Ryan Hiltenbrand , Anup Aggarwal , Yunchao Chang , Vibhor Mishra , Shilpa Narina , Melvin Thomas , Allister J Loughran , Ravi Kalathur , Kaiwen Yu , Suiping Zhou , Xusheng Wang , Anthony A High , Junmin Peng , Shondra M Pruett-Miller , Danette L Daniels , Marjeta Urh , Anang A Shelat , Charles G Mullighan , Kristin M Riching , Guido J R Zaman , Marcus Fischer , Jeffery M Klco , Zoran Rankovic
Journal: Nat Commun
PubMed ID: 38228616
Doi: 10.1038/s41467-024-44698-1
Products & Services: Custom Vector Construction   
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
Authors: Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang , Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao
Journal: Nature
PubMed ID: 37993710
Doi: 10.1038/s41586-023-06753-7
Products & Services: Gene Synthesis   
Structural basis of Gabija anti-phage defence and viral immune evasion
Authors: Sadie P Antine, Alex G Johnson, Sarah E Mooney, Azita Leavitt, Megan L Mayer, Erez Yirmiya, Gil Amitai, Rotem Sorek, Philip J Kranzusch
Journal: Nature
PubMed ID: 37992757
Doi: 10.1038/s41586-023-06855-2
Products & Services: Gene Synthesis   
A synthetic differentiation circuit in Escherichia coli for suppressing mutant takeover
Authors: David S Glass 1, Anat Bren 2, Elizabeth Vaisbourd 2, Avi Mayo 2, Uri Alon
Journal: Cell
PubMed ID: 38320549
Doi: 10.1016/j.cell.2024.01.024
Products & Services: Plasmid DNA Preparation   
Sirtuin 3 is required for the dexmedetomidine-mediated alleviation of inflammation and oxidative stress in nephritis
Authors: Kai Lu , Xinlong Li , Jie Wu
Journal: Immunity
PubMed ID: 38270316
Doi: 10.1002/iid3.1135
Products & Services: Custom DNA/RNA Oligos   
PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends
Authors: Nagaraja Chappidi 1, Thomas Quail 2, Simon Doll 3, Laura T Vogel 4, Radoslav Aleksandrov 5, Suren Felekyan 4, Ralf Kühnemuth 4, Stoyno Stoynov 5, Claus A M Seidel 4, Jan Brugués 6, Marcus Jahnel 3, Titus M Franzmann 1, Simon Alberti
Journal: Cell
PubMed ID: 38320550
Doi: 10.1016/j.cell.2024.01.015
Products & Services: Codon Optimization   
The CRISPR effector Cam1 mediates membrane depolarization for phage defence
Authors: Christian F. Baca, You Yu, Jakob T. Rostøl, Puja Majumder, Dinshaw J. Patel & Luciano A. Marraffini
Journal: Nature
PubMed ID: 38200316
Doi: 10.1038/s41586-023-06902-y
Products & Services: GenCrispr Cas9 Genome Editing   
Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria
Authors: Sabine Poerschke, Silke Oeljeklaus, Luis Daniel Cruz-Zaragoza, Alexander Schenzielorz, Drishan Dahal, Hauke Sven Hillen, Hirak Das, Laura Sophie Kremer, Anusha Valpadashi, Mirjam Breuer, Johannes Sattmann, Ricarda Richter-Dennerlein, Bettina Warscheid, Sven Dennerlein, Peter Rehling
Journal: Cell
PubMed ID: 38199007
Doi: 10.1016/j.molcel.2023.12.013
Products & Services: Gene Synthesis   
Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification
Authors: Jun Wang , Jinyong Huang , Yunlong Hu , Qianwen Guo , Shasha Zhang , Jinglin Tian , Yanqin Niu , Ling Ji , Yuzhong Xu , Peijun Tang , Yaqin He , Yuna Wang , Shuya Zhang , Hao Yang , Kang Kang , Xinchun Chen , Xinying Li , Ming Yang , Deming Gou
Journal: Nat Commun
PubMed ID: 38168054
Doi: 10.1038/s41467-023-44461-y
Products & Services: Gene Synthesis   

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