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Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif
Authors: Wuyang Shi , Shibo Sun , Haowen Liu , Yao Meng , Kangshuai Ren , Guoying Wang , Minghui Liu , Jiaqi Wu , Yue Zhang , Huang Huang , Meiyun Shi , Weiping Xu , Qiang Ma , Bingbing Sun , Jianqiang Xu
Journal: Redox biology
Doi: 10.1016/j.redox.2024.103050
Products & Services: Proteins, Expression, Isolation and Analysis   
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines
Authors: Gisele Nishiguchi , Lauren G Mascibroda , Sarah M Young , Elizabeth A Caine , Sherif Abdelhamed , Jeffrey J Kooijman , Darcie J Miller , Sourav Das , Kevin McGowan , Anand Mayasundari , Zhe Shi , Juan M Barajas , Ryan Hiltenbrand , Anup Aggarwal , Yunchao Chang , Vibhor Mishra , Shilpa Narina , Melvin Thomas , Allister J Loughran , Ravi Kalathur , Kaiwen Yu , Suiping Zhou , Xusheng Wang , Anthony A High , Junmin Peng , Shondra M Pruett-Miller , Danette L Daniels , Marjeta Urh , Anang A Shelat , Charles G Mullighan , Kristin M Riching , Guido J R Zaman , Marcus Fischer , Jeffery M Klco , Zoran Rankovic
Journal: Nat Commun
PubMed ID: 38228616
Doi: 10.1038/s41467-024-44698-1
Products & Services: Custom Vector Construction   
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
Authors: Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang , Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao
Journal: Nature
PubMed ID: 37993710
Doi: 10.1038/s41586-023-06753-7
Products & Services: Gene Synthesis   
Structural basis of Gabija anti-phage defence and viral immune evasion
Authors: Sadie P Antine, Alex G Johnson, Sarah E Mooney, Azita Leavitt, Megan L Mayer, Erez Yirmiya, Gil Amitai, Rotem Sorek, Philip J Kranzusch
Journal: Nature
PubMed ID: 37992757
Doi: 10.1038/s41586-023-06855-2
Products & Services: Gene Synthesis   
A synthetic differentiation circuit in Escherichia coli for suppressing mutant takeover
Authors: David S Glass 1, Anat Bren 2, Elizabeth Vaisbourd 2, Avi Mayo 2, Uri Alon
Journal: Cell
PubMed ID: 38320549
Doi: 10.1016/j.cell.2024.01.024
Products & Services: Plasmid DNA Preparation   
Sirtuin 3 is required for the dexmedetomidine-mediated alleviation of inflammation and oxidative stress in nephritis
Authors: Kai Lu , Xinlong Li , Jie Wu
Journal: Immunity
PubMed ID: 38270316
Doi: 10.1002/iid3.1135
Products & Services: Custom DNA/RNA Oligos   
Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification
Authors: Jun Wang , Jinyong Huang , Yunlong Hu , Qianwen Guo , Shasha Zhang , Jinglin Tian , Yanqin Niu , Ling Ji , Yuzhong Xu , Peijun Tang , Yaqin He , Yuna Wang , Shuya Zhang , Hao Yang , Kang Kang , Xinchun Chen , Xinying Li , Ming Yang , Deming Gou
Journal: Nat Commun
PubMed ID: 38168054
Doi: 10.1038/s41467-023-44461-y
Products & Services: Gene Synthesis   
Influenza a Neuraminidase-Based Bivalent mRNA Vaccine Induces Th1-Type Immune Response and Provides Protective Effects in Mice
Authors: Mingyang Li , Mengyuan Liu , Shaohui Song, Ruirui Zhao, Yun Xie, Jing Liu, Lilan Xu, Xuefeng Ma, Mingyu Song, Jian Zhou and Guoyang Liao
Journal: vaccine
Doi: 10.3390/vaccines12030300
Products & Services: Gene Synthesis   
Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs
Authors: Yingli Zhu, Thibaut Burg, Katrien Neyrinck, Tim Vervliet, Fatemeharefeh Nami, Ellen Vervoort, Karan Ahuja, Maria Livia Sassano, Yoke Chin Chai, Arun Kumar Tharkeshwar, Jonathan De Smedt, Haibo Hu, Geert Bultynck, Patrizia Agostinis, Johannes V. Swinnen, Ludo Van Den Bosch, Rodrigo Furtado Madeiro da Costa & Catherine Verfaillie
Journal: Acta Neuropathologica
PubMed ID: 38395965
Doi: 10.1007/s00401-023-02666-x
Products & Services: Antibody Modification and Purification Services   
LATS2 condensates organize signalosomes for Hippo pathway signal transduction
Authors: Min Qin, Ershuo Geng, Jingning Wang, Man Yu, Tianqi Dong, Shasha Li, Xiao Zhang, Jiaming Lin, Mingjun Shi, Juebei Li, Huixia Zhang, Lian Chen, Xiaolei Cao, Liu Huang, Mingwei Wang, Yan Li, Xiang-ping Yang, Bin Zhao & Shuguo Sun
Journal: Nature Chemical Biology
PubMed ID: 38200110
Doi: 10.1038/s41589-023-01516-x
Products & Services: Gene Synthesis   

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