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Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif
Authors: Wuyang Shi , Shibo Sun , Haowen Liu , Yao Meng , Kangshuai Ren , Guoying Wang , Minghui Liu , Jiaqi Wu , Yue Zhang , Huang Huang , Meiyun Shi , Weiping Xu , Qiang Ma , Bingbing Sun , Jianqiang Xu
Journal: Redox biology
Doi: 10.1016/j.redox.2024.103050
Products & Services: Proteins, Expression, Isolation and Analysis   
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines
Authors: Gisele Nishiguchi , Lauren G Mascibroda , Sarah M Young , Elizabeth A Caine , Sherif Abdelhamed , Jeffrey J Kooijman , Darcie J Miller , Sourav Das , Kevin McGowan , Anand Mayasundari , Zhe Shi , Juan M Barajas , Ryan Hiltenbrand , Anup Aggarwal , Yunchao Chang , Vibhor Mishra , Shilpa Narina , Melvin Thomas , Allister J Loughran , Ravi Kalathur , Kaiwen Yu , Suiping Zhou , Xusheng Wang , Anthony A High , Junmin Peng , Shondra M Pruett-Miller , Danette L Daniels , Marjeta Urh , Anang A Shelat , Charles G Mullighan , Kristin M Riching , Guido J R Zaman , Marcus Fischer , Jeffery M Klco , Zoran Rankovic
Journal: Nat Commun
PubMed ID: 38228616
Doi: 10.1038/s41467-024-44698-1
Products & Services: Custom Vector Construction   
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
Authors: Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang , Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao
Journal: Nature
PubMed ID: 37993710
Doi: 10.1038/s41586-023-06753-7
Products & Services: Gene Synthesis   
Structural basis of Gabija anti-phage defence and viral immune evasion
Authors: Sadie P Antine, Alex G Johnson, Sarah E Mooney, Azita Leavitt, Megan L Mayer, Erez Yirmiya, Gil Amitai, Rotem Sorek, Philip J Kranzusch
Journal: Nature
PubMed ID: 37992757
Doi: 10.1038/s41586-023-06855-2
Products & Services: Gene Synthesis   
A synthetic differentiation circuit in Escherichia coli for suppressing mutant takeover
Authors: David S Glass 1, Anat Bren 2, Elizabeth Vaisbourd 2, Avi Mayo 2, Uri Alon
Journal: Cell
PubMed ID: 38320549
Doi: 10.1016/j.cell.2024.01.024
Products & Services: Plasmid DNA Preparation   
Sirtuin 3 is required for the dexmedetomidine-mediated alleviation of inflammation and oxidative stress in nephritis
Authors: Kai Lu , Xinlong Li , Jie Wu
Journal: Immunity
PubMed ID: 38270316
Doi: 10.1002/iid3.1135
Products & Services: Custom DNA/RNA Oligos   
9S1R nullomer peptide induces mitochondrial pathology, metabolic suppression, and enhanced immune cell infiltration, in triple-negative breast cancer mouse model
Authors: Nilufar Ali, Cody Wolf, Swarna Kanchan, Shivakumar R Veerabhadraiah, Laura Bond, Matthew W Turner, Cheryl L Jorcyk, Greg Hampikian
Journal: Biomed Pharmacother
PubMed ID: 38118350
Doi: 10.1016/j.biopha.2023.115997.
Products & Services: Peptide Synthesis   
Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α
Authors: Zuen Ren, Malindrie Dharmaratne, Huizhi Liang, Outhiriaradjou Benard, Miriam Morales-Gallego, Kimita Suyama, Viney Kumar, Atefeh Taherian Fard, Ameya S Kulkarni, Michael Prystowsky, Jessica C Mar, Larry Norton, Rachel B Hazan
Journal: Br J Cancer
PubMed ID: 38238426
Doi: 10.1038/s41416-023-02522-5
Products & Services: ORF cDNA Clones/MolecularCloud   
Revamped mini-αA-crystallin showed improved skin permeation and therapeutic activity against melittin-induced toxicity
Authors: Tenzin Tender, Rakesh Ravishankar Rahangdale, Madhavan Nampoothiri, Ruchira Raychaudhuri, Srinivas Mutalik, Krishna Sharma, Raghu Chandrashekar H
Journal: Toxicon
PubMed ID: 38211805
Doi: 10.1016/j.toxicon.2024.107611
Products & Services: Gene Synthesis   
Surface-modified measles vaccines encoding oligomeric, prefusion-stabilized SARS-CoV-2 spike glycoproteins boost neutralizing antibody responses to Omicron and historical variants, independent of measles seropositivity
Authors: Miguel Á Muñoz-Alía, Rebecca A Nace, Baskar Balakrishnan, Lianwen Zhang, Nandakumar Packiriswamy, Gagandeep Singh, Prajakta Warang, Ignacio Mena, Riya Narjari, Rianna Vandergaast, Kah-Whye Peng, Adolfo García-Sastre, Michael Schotsaert, Stephen J Russell
Journal: MBio
PubMed ID: 38193729
Doi: 10.1128/mbio.02928-23
Products & Services: Gene Synthesis   

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