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Gene Synthesis> | ... tag) [35]. A gene coding for a recombinant protein corresponding to amino acids 43–487 of the ectodomain of PvAMA–1 was synthesized by GenScript USA Inc. (Piscataway, NJ) and expressed in Pichia pastoris [11]. Region ... | Get A Quote |
The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally acquired humoral immune response against proteins of the asexual stage of Plasmodium vivax. A total of 319 individuals living in an area of malaria transmission in the Brazilian Amazon were genotyped for four SNPs in the genes CD40, CD40L, BLYS and CD86. In addition, IgG antibodies against P. vivax apical me... More