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Gene Synthesis> | ... 2.2. pKa Determination. The pKa of the MMP XCXX thiol containing tag sequences (XCXX), Ac-GCRDG-NH¬2 (CRD), Ac-GDCDDG-NH2 (DCDD), Ac-GECEEG-NH2 (ECEE) (Genscript, Piscataway, NJ) was determined as previously described. ... | Get A Quote |
The development of synthetic hydrogels analogs for the extracellular matrix has proven a useful and important tool to study the role of specific signals on biological outcomes in vitro and to serve as scaffolds for tissue repair. Although the importance of physical properties (e.g. microstructure and stiffness) in the micro and nano scale on cell fate has been widely reported, bulk modulus measurements are typically used to characterize hydrogels. Thus, the physical properties of hydrogels have not been widely tested for their controlled physical properties in the nano and micron scales. In this report, we show that although fast Michael-type addition crosslinked hydrogels appear uniform by bulk modulus reading... More