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Ubiquitin-conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection.

Virol. J.. 2018-01;

FengTingting，DengLei，LuXiaochuan，PanWen，WuQihan，DaiJian

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Catalog Antibody	… The following antibodies were used for western blotting: anti-human GAPDH polyclone antibody (Proteintech, USA), His-tag polyclone antibody (GenScript, USA), HA-probe mouse monoclonal antibody (Santa Cruz, USA), anti-Flag-tag (Sigma-Aldrich, USA), RIG-I pathway …	Get A Quote

摘要

Viral infection activates innate immune pathways and interferons (IFNs) play a pivotal role in the outcome of a viral infection. Ubiquitin modifications of host and viral proteins significantly influence the progress of virus infection. Ubiquitin-conjugating enzyme E2s (UBE2) have the capacity to determine ubiquitin chain topology and emerge as key mediators of chain assembly.