Products/Services Used | Details | Operation |
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Custom DNA/RNA Oligos> | … extracellular domain (GenBank: {"type":"entrez-nucleotide","attrs":{"text":"Z25524.1","term_id":" 396767","term_text":"Z25524.1"}}Z25524.1) corresponding to amino acids 19–161, plus a leader and a HA tag, was optimized and synthesized by GenScript (Piscataway, NJ, USA) … | Get A Quote |
Current oncolytic virotherapy is primarily administered by intratumoral injection. However, systemic delivery is desirable for treating patients, particularly for those who have developed metastatic diseases. Several components are impeding the systemic delivery efficiency of oncolytic viruses. Chief among them is the rapid clearance of viral particles by the host's mononuclear phagocyte system (MPS). We explored the possibility of genetically engrafting CD47, a "don't eat me" signal molecule, to the membrane envelop of an oncolytic herpes simplex virus (HSV) to enable it to escape from the MPS for systemic delivery. Our results show that this modification indeed allows the virus to be more efficiently ... More