Langerin， a C-type lectin receptor (CLR) expressed in a subset of dendritic cells (DCs)， binds to glycan ligands for pathogen capture and clearance. Previous studies revealed that langerin has an unusual binding affinity toward 6-sulfated galactose (Gal)， a structure primarily found in keratan sulfate (KS). However， details and biological outcomes of this interaction have not been characterized. Based on a recent discovery that the disaccharide L4， a KS component that contains 6-sulfo-Gal， exhibits anti-inflammatory activity in mouse lung， we hypothesized that L4-related compounds are useful tools for characterizing the langerin-ligand interactions and their therapeutic application.
Langerin， a C-type lectin receptor (CLR) expressed in a subset of dendritic cells (DCs)， binds to glycan ligands for pathogen capture and clearance. Previous studies revealed that langerin has an unusual binding affinity toward 6-sulfated galactose (Gal)， a structure primarily found in keratan sulfate (KS). However， details and biological outcomes of this interaction have not been characterized. Based on a recent discovery that the disaccharide L4， a KS component that contains 6-sulfo-Gal， exhibits anti-inflammatory activity in mouse lung， we hypothesized that L4-related compounds are useful tools for characterizing the langerin-ligand interactions and their therapeutic application.
