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Gene Synthesis> | … 2.2. Plasmid Information. Site-directed mutagenesis to the open reading frame of 37 LR was performed by Genscript. After codon optimization, wild type 37 LR, K11R, K42R, and K212R plasmids were generated in a pcDNA 3.1 backbone with a c-terminal hexahistidine tag … | Get A Quote |
There is a putative precursor to mature receptor relationship between 37 Laminin Receptor (LR) and 67 LR. As such, the pair are frequently referred to as a single entity, the 37/67 kDa Laminin Receptor (37/67 LR) and 67 LR was identified as a laminin binding entity. 37/67 LR has been of clinical interest for many years, as 37/67 LR is a prognostic indicator for many cancers including breast, lung, colon, and prostate. However, the genesis of 67 LR is controversial, and confounded by its stability under SDS-PAGE conditions, a lack of splice variants, and the existence of post-translational modifications that cannot account for the mass discrepancy between 37 and 67 LR. In the present work... More