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Catalog Antibody> | … Freund's adjuvant. Plates were washed 3 times with PBS'T before incubation with mouse anti-His tag antibody (GenScript, Nanjing, China) and HRP-conjugated goat anti-mouse IgG was used as the secondary antibody. The … | Get A Quote |
Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important infectious diseases impacting the swine industry worldwide. Prevention and control of PRRS have been problematic, as vaccination has achieved little success. MYH9 (encoded by the gene MYH9) is an essential cellular factor for PRRS virus (PRRSV) infection. The MYH9 C-terminal domain (designated PRA) interacts with viral glycoprotein 5 (GP5), a major PRRSV envelope protein. In this study, we investigated whether soluble PRA could serve as a novel blocking agent of PRRSV infection. Our data showed that preincubation of PRRSV with PRA inhibited virus infection of susceptible cells in a dose-dependent manner. Notably... More