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Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety

Mol Metab. 2017-11; 
MoirLee, BochukovaElena G, DumbellRebecca, BanksGareth, BainsRasneer S, NolanPatrick M, ScudamoreCheryl, SimonMichelle, WatsonKimberly A, KeoghJulia, HenningElana, HendricksAudrey, O'RahillyStephen, BarrosoInês, , SullivanAdrienne E, BerstenDavid C, WhitelawMurray L, KirschSusan, BentleyElizabeth, FarooqiI Sadaf, CoxRog
Products/Services Used Details Operation
Gene Synthesis … of human OTP with C-terminal 3XFlag tags and respective gene variants were synthesized and cloned into pcDNA5/Frt/TO (Invitrogen), and Luciferase reporter constructs 8xnp and 6xP3 were synthesized and cloned into vector pLuc-MCS (Stratagene) by GenScript (NJ, USA) … Get A Quote

摘要

Genetic studies in obese rodents and humans can provide novel insights into the mechanisms involved in energy homeostasis.

关键词

Energy balance,Human mutation,Mouse model,OTP,Obesity,Oxytocin,Vasopre