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Simvastatin Strongly Augments Proapoptotic, Anti-inflammatory and Cytotoxic Activity of Oxicam Derivatives in Doxorubicin-resistant Colon Cancer Cells.

Anticancer Res.. 2019; 
Środa-PomianekKamila,MichalakKrystyna,Palko-ŁabuzAnna,UrygaAnna,Szczęśniak-SięgaBerenika,Wesołowska
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Proteins, Expression, Isolation and Analysis … Cytotoxicity of dimethyl sulfoxide to LoVo/Dx cells was found to be negligible. Caspase-3 activation assay. The activity of caspase-3 was analyzed with the use of a commercially available kit (GenScript, Piscataway, NJ, USA) … Get A Quote

摘要

Incidence of cancer is still increasing. Chemotherapy is often unsuccessful; moreover, anticancer drugs cause serious side-effects. It is necessary to develop effective agents for combination therapies that would increase antitumor effects of treatment and reduce its side-effects.

关键词

Oxicam derivatives,apoptosis,cancer combination therapy,cyclo-oxygenase-2,simvast