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Efficient production of glycyrrhetinic acid in metabolically engineered Saccharomyces cerevisiae via an integrated strategy.

Microb. Cell Fact.. 2019-05;

WangCaixia，SuXinyao，SunMengchu，ZhangMengting，WuJiajia，XingJianmin，WangYing，XueJianping，LiuXia，SunWei，ChenSh

Products/Services Used	Details	Operation
Codon Optimization	To improve gene expression in S. cerevisiae we optimized the codons CYP88D6 (OP-CYP88D6) and CYP72A154 (OP-CYP72A154) for genes cloning into pUC57, which were synthesized by GenScript (GenScript, Nanjing, China).	Get A Quote

摘要

Glycyrrhetinic acid (GA) is the most important ingredient in licorice due to its outstanding anti-inflammatory activity and wide application in the medicine and cosmetics industries. Contemporary industrial production of GA by acid hydrolysis of glycyrrhizin which was extracted from Glycyrrhiza plants， is not environment-friendly and devastates farmland since the Glycyrrhiza rhizomes grow up to 10 m underground.