Characteristics of parathyroid hormone-1 receptor agonists and antagonists.

Parathyroid hormone-1 receptor (PTH1R) is a member of B G protein-coupled receptors. The agonistic activation of the PTH1R results in the production and secretion of osteoclast-stimulating cytokines while antagonists may be used to treat bone metastases， hypercalcemia， cachexia and hyperparathyroidism. We built pharmacophore models and investigated the characteristics of PTH1R agonists and antagonists. The agonist model consists of three hydrophobic points， one hydrogen bond acceptor and one positive ionizable point. The antagonist model consists of one hydrogen bond donor and three hydrophobic points. The features of the two models are similar， but the hydrogen bond acceptor， which is the main difference between PTH1R agonists and antagonists， suggests it may be essential for the agonist.