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Altered thymic CD4 T-cell recovery after allogeneic hematopoietic stem cell transplantation is critical for nocardiosis.

Curr Res Transl Med. 2019-06;

RousselXavier，DaguindauEtienne，BerceanuAna，DesbrossesYohan，SaasPhilippe，FerrandChristophe，SeillesEstelle，PouthierFabienne，DeconinckEric，LarosaFab

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Proteins, Expression, Isolation and Analysis	… The remaining cells were rested for 3 days in 24-well plates with 40 IU/ml IL-2 (Genscript inc., Piscataway, NJ, USA) and irradiated (30Gy) autologous feeder cells at a ratio of 1:1 before assessment of anti-viral responses using tetramer staining, ELISPOT, cytotoxicity and …	Get A Quote

摘要

Nocardia affects immunocompromised human host exhibiting an altered cell-mediated immunity. Infectious risk after allogeneic hematopoietic cell transplantation (AHCT) is significantly correlated to the recovery status of donor-derived immune system， especially CD4 T-cells reconstitution and thymopoiesis. The purpose of this paper is to highlight a lack of cell-mediated immunity recovery for patients presenting a nocardiosis compared to a control cohort.