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Protein complexes including PGRMC1 and actin-associated proteins are disrupted by AG-205

Biochem Biophys Res Commun. 2020;

Teakel SL, Ludescher M, Thejer BM, Poschmann G, Forwood JK, Neubauer H, Cahill MA.

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Catalog Antibody	… The antibody-protein complexes were immunoprecipitated by collecting the magnetic beads with a magnetic stand (GenScript, M00140) and washed in ice-cold PBS containing 005% Tween20 on an orbital rotator for 20min …	Get A Quote

摘要

PGRMC1 is a protein from the MAPR family with a range of cellular functions. PGRMC1 has been described to play a role in fertility, neuroprotection, steroidogenesis, membrane trafficking and in cancer cell biology. PGRMC1 represents a likely key regulator of cell metabolism and proliferation, as well as a potential target for anti-cancer therapies. To further understand the functions of PGRMC1 and the mechanism of the small molecule inhibitor of PGRMC1, AG-205, proteins differentially bound to PGRMC1 were identified following AG-205 treatment of MIA PaCa-2 cells. Our results suggest that AG-205 influences PGRMC1 interactions with the actin cytoskeleton. The binding of two PGRMC1-associated proteins that suppor... More