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Gene Synthesis> | Full-length N-terminal FLAG-tagged single mutation constructs harboring substitutions tyrosine 77 to phenylalanine (cScrt2-Y77F) or glutamate (cScrt2-Y77E), or serine 78 to alanine (cScrt2-S78A) or aspartate (cScrt2-S78D) were synthesized by GenScript USA Inc. (Piscataway, NJ). | Get A Quote |
The Snail superfamily of transcription factors have a modular organization and their similarities and divergences are the basis for subdividing the superfamily into the Snail1/2 and Scratch families. As it is generally accepted that the Snail and Scratch families originated through gene duplication, understanding the functional contribution of each module could provide us with further insight about the molecular and functional evolution of the Snail superfamily. Thus, in this work, we investigated the function of the SNAG and SCRATCH domains in chicken Scratch2. Through evolutionary comparison analysis we identified a novel HINGE domain that lies between the SNAG and SCRATCH domain. Similar to members of the Sn... More