Dip-Pen Nanolithography of Bioactive Peptides on Collagen-Terminated Retinal Membrane.

Dip-pen nanolithography is used to directly modify freshly dissected eye tissues with biologically active collagen-binding peptide molecules. The results address the challenge of surface heterogeneity and utilize dip-pen nanolithography to control the localization and concentration of molecules on a collagen-terminated tissue-derived surface. This method can allow the development of scaffolds for treatment of age-related macular degeneration.

biomedical materials;dip-pen lithography;scanning probe microscopy;tissue engineering peptides