| Products/Services Used | Details | Operation |
|---|---|---|
| Peptide Synthesis | … Representative flow plots (J) and summary data (K) of TNF and IFN-γ + cells among … FcyRIIB staining on human PBMCs was performed using anti-human CD32 mAb (clone FLI8.26 … In some experiments, cells were activated with 30 nM OVA SIINFEKL peptide (GenScript) and 10 … | Get A Quote |
Fc receptors (FcRs) and the microbiome are both known to have an effect on the development and progression of cancers. Checkpoint inhibitors are a novel class of therapeutics which are used to combat cancer and are integrally linked to both FcRs and the microbiome. The use of checkpoint inhibitors has grown exponentially over the past decade, although many host factors affect both the efficacy and the safety of these therapeutics. Some of these host factors, including the microbiome and the expression of FcRs, are currently being investigated. Here we discuss the current understanding of FcRs (particularly the inhibitory FcγRIIB) and the microbiome in context of T cell immunity, inflammation, cancer, and check... More
