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Mitochondrial GPAT-derived LPA controls auxin-dependent embryonic and postembryonic development

Proc Natl Acad Sci U S A. 2022-12;

Qianru Jia , Yang Bai , Hui Xu , Qingyun Liu , Wenyan Li , Teng Li , Feng Lin , Like Shen , Wei Xuan , Wenhua Zhang , Qun Zhang

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Proteins, Expression, Isolation and Analysis	Lipid–protein binding assay PIN1CL, truncated PIN1CLs, and mutant PIN1CLs were expressed and purified with Ni-IDA resin (Genscript Biotech, Piscataway, NJ, USA).	Get A Quote

摘要

Membrane properties are emerging as important cues for the spatiotemporal regulation of hormone signaling. Lysophosphatidic acid (LPA) evokes multiple biological responses by activating G protein-coupled receptors in mammals. In this study, we demonstrated that LPA derived from the mitochondrial glycerol-3-phosphate acyltransferases GPAT1 and GPAT2 is a critical lipid-based cue for auxin-controlled embryogenesis and plant growth in Arabidopsis thaliana. LPA levels decreased, and the polarity of the auxin efflux carrier PIN-FORMED1 (PIN1) at the plasma membrane (PM) was defective in the gpat1 gpat2 mutant. As a consequence of distribution defects, instructive auxin gradients and embryonic and postembryonic devel... More