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Cytosolic 5′-nucleotidase 1A autoimmunity in sporadic inclusion body myositis.

Ann Neurol.. 2013-03; 73(3):408-18

Larman HB, Salajegheh M, Nazareno R, Lam T, Sauld J, Steen H, Kong SW, Pinkus JL, Amato AA, Elledge SJ, Greenberg SA. Department of Genetics, Harvard University Medical School, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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摘要

We previously identified a circulating autoantibody against a 43 kDa muscle autoantigen in sporadic inclusion body myositis (IBM) and demonstrated the feasibility of an IBM diagnostic blood test. Here, we sought to identify the molecular target of this IBM autoantibody, understand the relationship between IBM autoimmunity and muscle degeneration, and develop an IBM blood test with high diagnostic accuracy.