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Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease

Authors: Emre Fertan; Jeff Y. L. Lam; Giulia Albertini; Maarten Dewilde; Yunzhao Wu; Oluwatomi E. S. Akingbade; Dorothea B ken; Elizabeth A. English; Bart De Strooper; David Klenerman

Journal: Alzheimer's & Dementia

PubMed ID: 40237235

Doi: 10.1002/alz.70086

Products & Services: Protein and Antibody Isolation

Engineered nucleocytosolic vehicles for loading of programmable editors

Authors: Julian Geilenkeuser, Niklas Armbrust, Emily Steinmaßl, Samuel W Du, Sebastian Schmidt, Eva Maria Hildegard Binder, Yuchun Li, Niklas Wilhelm Warsing, Stephanie Victoria Wendel, Florian von der Linde, Elisa Marie Schiele, Xiya Niu, Luisa Stroppel, Oleksandr Berezin, Tobias Heinrich Santl, Tanja Orschmann, Keith Nelson, Christoph Gruber, Grazyna Palczewska, Carolline Rodrigues Menezes, Eleonora Risaliti, Zachary J Engfer, Naile Koleci, Andrea Schmidts, Arie Geerlof, Krzysztof Palczewski, Gil Gregor Westmeyer, Dong-Jiunn Jeffery Truong

Journal: Cell

PubMed ID: 40209705

Doi: 10.1016/j.cell.2025.03.015

Products & Services: Protein Electrophoresis and Western

S-ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide-Induced Depression Via Targeting SIRT2

Authors: Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang

Journal: Advanced Science

PubMed ID: 40171943

Doi: 10.1002/advs.202416481

Products & Services: Protein and Antibody Isolation

A non-tethering role for the Drosophila Pol θ linker domain in promoting damage resolution

Authors: Justin R Blanch, Nicholas Woodward, Manan Krishnamurthy, Mitch McVey

Journal: Nucleic Acids Research

PubMed ID: 40275613

Doi: 10.1093/nar/gkaf304

Products & Services: Protein Electrophoresis and Western

Inhibiting Chemotherapy Immune Tolerance and Reversing Tumor Microenvironment by Macrophage-Targeted Nanohybrid Systems for Enhancing Tumor Chemo-Immunotherapy

Authors: You-Teng Qin, Zhi-Yong Rao, Jia-Xin An, Shi-Man Zhang, Yu-Zhang Wang, Ting Pan, and Xian-Zheng Zhang

Journal: Advanced Functional Materials

Doi: doi.org/10.1002/adfm.202501954

Products & Services: Recombinant Proteins

Ara-C suppresses H3 K27–altered spinal cord diffuse midline glioma growth and enhances immune checkpoint blockade sensitivity

Authors: Bo Pang, Yilin Wu, SongYuan An, Yuzhou Chang, Hao Yan, Han Lin, Zheng Zhao, Fan Wu, Qing Chang, Wenqing Jia, Tao Jiang, Yongzhi Wang, Ruichao Chai

Journal: SCIENCE ADVANCES

PubMed ID: 40238864

Doi: 10.1126/sciadv.adu3956

Products & Services: Protein Electrophoresis and Western

Engineering aptamer-directed phosphatase recruiting chimeras: a strategy for modulating receptor function and overcoming drug resistance

Authors: Zhilan Zhou, Yichang Liu, Ya Wang, Hang Jiang, Tingting Chen, Yingdi Zhu, Ting Fu, Juan Li

Journal: Nature Communications

PubMed ID: 40280908

Doi: 10.1038/s41467-025-59098-2

Products & Services: Protein Electrophoresis and Western

Molecular mechanisms of the viral encoded chaperone 100K in capsid folding and assembly of adenovirus

Authors: Haining Li , Luyuan Shao , Zhe Liu , Qi Liu , Ye Xiang

Journal: Nat Commun

PubMed ID: 40301360

Doi: 10.1038/s41467-025-59301-4

Products & Services: Protein and Antibody Isolation

Molecular determinants for the association of human hormone-sensitive lipase with lipid droplets

Authors: Han Peng, Qikui Xu, Ting Zhang, Jiakai Zhu, Jinheng Pan, Xiaoyu Guan, Shan Feng, Jianping Wu, Qi Hu

Journal: nature COMMUNICATION

PubMed ID: 40221426

Doi: 10.1038/s41467-025-58887-z

Products & Services: Protein and Antibody Isolation

Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity

Authors: Xindi Zhou, Huijing Zhang, Yaru Wang, Danni Wang, Zhiqiao Lin, Yuchao Zhang, Yubin Tang, Jianping Liu, Yu-Feng Yao, Yixiao Zhang & Lifeng Pan

Journal: Nature Communications

PubMed ID: 40164614

Doi: 10.1038/s41467-025-58432-y

Products & Services: Protein Electrophoresis and Western