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Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease
Authors: Takashi Kei Kishimoto, Max Fournier, Alicia Michaud, Gina Rizzo, Christopher Roy, Teresa Capela, Natasha Nukolova, Ning Li, Liam Doyle, Fen-Ni Fu, Derek VanDyke, Peter G Traber, Jamie B Spangler, Sheldon S Leung, Petr O Ilyinskii
Journal: J Autoimmun
PubMed ID: 37844543
Doi: 10.1016/j.jaut.2023.103125
Products & Services: Proteins, Expression, Isolation and Analysis   
Single Amino Acid Mutation Decouples Photochemistry of the BLUF Domain from the Enzymatic Function of OaPAC and Drives the Enzyme to a Switched-on State
Authors: Jinnette Tolentino Collado, Emoke Bodis, Jonatan Pasitka, Mihaly Szucs, Zsuzsanna Fekete, Nikolett Kis-Bicskei, Elek Telek, Kinga Pozsonyi, Sofia M Kapetanaki, Greg Greetham, Peter J Tonge, Stephen R Meech, Andras Lukacs
Journal: J Mol Biol
PubMed ID: 37827329
Doi: 10.1016/j.jmb.2023.168312
Products & Services: Proteins, Expression, Isolation and Analysis   
Rational Design of Taxadiene Hydroxylase by Ancestral Enzyme Construction and the Elucidation of Key Amino Acids
Authors: Zihan Zhang, Longhao Huang, Zhi-Jun Zhang, Jian-He Xu, Hui-Lei Yu
Journal: Biochemistry
PubMed ID: 37902563
Doi: 10.1021/acs.biochem.3c00411
Products & Services: Proteins, Expression, Isolation and Analysis   
FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design
Authors: Wern Hann Ng, Xiang Liu, Zheng L Ling, Camilla N O Santos, Lucas S Magalhães, Andrew J Kueh, Marco J Herold, Adam Taylor, Joseph R Freitas, Sandra Koit, Sainan Wang, Andrew R Lloyd, Mauro M Teixeira, Andres Merits, Roque P Almeida, Nicholas J C King, Suresh Mahalingam
Journal: Nat Commun
PubMed ID: 37884534
Doi: 10.1038/s41467-023-42330-2
Products & Services: Proteins, Expression, Isolation and Analysis   
Biochemical and biophysical properties of a rare TTRA81V mutation causing mild transthyretin amyloid cardiomyopathy
Authors: Qiuyan Sha, Yanli Zhang, Mengdie Wang, Jialu Sun, Yunlong Zhang, Xinxin Zhang, Ning Wang, Yu Liu, Ying Liu
Journal: ESC Heart Fail
PubMed ID: 37827496
Doi: 10.1002/ehf2.14543
Products & Services: Proteins, Expression, Isolation and Analysis   
Industry updates from the field of stem cell research and regenerative medicine in August 2023
Authors: Dusko Ilic, Mirjana Liovic
Journal: Regen Med
PubMed ID: 37786963
Doi: 10.2217/rme-2023-0181
Products & Services: Proteins, Expression, Isolation and Analysis   
A newly identified ferritin L-subunit variant results in increased proteasomal subunit degradation, impaired complex assembly, and severe hypoferritinemia
Authors: Dayana Shagidov, Noga Guttmann-Raviv, Séverine Cunat, Liora Frech, Muriel Giansily-Blaizot, Niraj Ghatpande, Gili Abelya, Gabriel A Frank, Patricia Aguilar Martinez, Esther G Meyron-Holtz
Journal: Am J Hematol
PubMed ID: 37867341
Doi: 10.1002/ajh.27124
Products & Services: Proteins, Expression, Isolation and Analysis   
Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens
Authors: Longlong Li, Ze Lu, Yulei Wang, Ying Yang, Huihui Wang, Haitian Ma
Journal: Poult Sci
PubMed ID: 37984004
Doi: 10.1016/j.psj.2023.103251
Products & Services: Proteins, Expression, Isolation and Analysis   
Condensation of the N-terminal domain of human topoisomerase 1 is driven by electrostatic interactions and tuned by its charge distribution
Authors: Greta Bianchi, Marco Mangiagalli, Diletta Ami, Junaid Ahmed, Silvia Lombardi, Sonia Longhi, Antonino Natalello, Peter Tompa, Stefania Brocca
Journal: Int J Biol Macromol
PubMed ID: 38287572
Doi: 10.1016/j.ijbiomac.2023.127754
Products & Services: Proteins, Expression, Isolation and Analysis   
Unfolding of an RNA G-quadruplex motif in the negative strand genome of porcine reproductive and respiratory syndrome virus by host and viral helicases to promote viral replication
Authors: Puxian Fang, Congbao Xie, Ting Pan, Ting Cheng, Wei Chen, Sijin Xia, Tong Ding, Junkang Fang, Yanrong Zhou, Liurong Fang, Dengguo Wei, Shaobo Xiao
Journal: Nucleic Acids Res
PubMed ID: 37739415
Doi: 10.1093/nar/gkad759
Products & Services: Proteins, Expression, Isolation and Analysis   

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