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Discovery of a 6-Aminobenzo[ b ]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities

Authors: Patrik Oleksak; David Rysanek; Marketa Vancurova; Pavla Vasicova; Alexandra Urbancokova; Josef Novak; Dominika Maurencova; Pavel Kashmel; Jana Houserova; Romana Mikyskova; Ondrej Novotny; Milan Reinis; Pavel Juda; Miroslav Hons; Jirina Kroupova; David Sedlak; Tetyana Sulimenko; Pavel Draber; Marketa Chlubnova; Eugenie Nepovimova; Kamil Kuca; Miroslav Lisa; Rudolf Andrys; Tereza Kobrlova; Ondrej Soukup; Jiri Janousek; Lukas Prchal; Jiri Bartek; Kamil Musilek; Zdenek Hodny

Journal: ACS pharmacology & translational science

PubMed ID: 39296273

Doi: 10.1021/acsptsci.4c00190

Products & Services: Monoclonal Antibody Services

Novel peptide inhibitor for the Chikungunya virus nsP2 protease: Identification and characterization

Authors: Mohammadamin Mastalipour; Ian Gering; M nika Aparecida Coronado; Jorge Enrique Hern ndez Gonz lez; Dieter Willbold; Raphael Josef Eberle

Journal: Current Research in Microbial Sciences

PubMed ID: 40165933

Doi: 10.1016/j.crmicr.2025.100376

Products & Services: Peptide Synthesis

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

Authors: Colin Sheehan; Lyndon Hu; Guillaume Cognet; Grace Croley; Thao Trang Nguyen; Anika Thomas-Toth; Darby Agovino; Patrick B. Jonker; Mumina Sadullozoda; Leah M. Ziolkowski; James K. Martin; Alica K. Beutel; Ranya Dano; Mohammed A. Khan; Christopher J. Halbrook; Kay F. Macleod; Christopher R. Weber; James L. LaBelle; Alexander Muir

Journal: biorxiv

PubMed ID: 40964288

Doi: 10.1101/2025.09.04.673818

Products & Services: Peptide Synthesis

High Throughput Screening for SARS-CoV-2 Helicase Inhibitors

Authors: Yuka Otsuka; Eunjung Kim; Austin Krueger; Justin Shumate; Chao Wang; Bilel Bdiri; Sultan Ullah; HaJeung Park; Louis Scampavia; Thomas D. Bannister; Donghoon Chung; Timothy P. Spicer

Journal: SLAS discovery : advancing life sciences R & D

PubMed ID: 39173831

Doi: 10.1016/j.slasd.2024.100180

High Throughput Screening for SARS-CoV-2 Helicase Inhibitors

Authors: Yuka Otsuka; Eunjung Kim; Austin Krueger; Justin Shumate; Chao Wang; Bilel Bdiri; Sultan Ullah; HaJeung Park; Louis Scampavia; Thomas D. Bannister; Donghoon Chung; Timothy P. Spicer

Journal: SLAS discovery : advancing life sciences R & D

PubMed ID: 39173831

Doi: 10.1016/j.slasd.2024.100180

Novel peptide inhibitor for the Chikungunya virus nsP2 protease: Identification and characterization

Authors: Mohammadamin Mastalipour; Ian Gering; M nika Aparecida Coronado; Jorge Enrique Hern ndez Gonz lez; Dieter Willbold; Raphael Josef Eberle

Journal: Current Research in Microbial Sciences

PubMed ID: 40165933

Doi: 10.1016/j.crmicr.2025.100376

Products & Services: Peptide Synthesis

Human Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin

Authors: Sabine Pellett; Michael P. Schwartz; William H. Tepp; Richard Josephson; Jacob M. Scherf; Christina L. Pier; James A. Thomson; William L. Murphy; Eric A. Johnson

Journal: Scientific REPORTS

PubMed ID: 26411797

Doi: 10.1038/srep14566

Products & Services: Peptide Synthesis

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

Journal: biorxiv

PubMed ID: 40964288

Doi: 10.1101/2025.09.04.673818

Products & Services: Peptide Synthesis

Integrative analysis of the therapeutic mechanisms of Astragaloside IV in idiopathic pulmonary fibrosis via network pharmacology and molecular validation

Authors: Shanshan Chen; Jin Yan; Jing Zhang; Yiwen Ma; Yiliang Su; Yiming Yu

Journal: Scientific REPORTS

PubMed ID: 41224967

Doi: 10.1038/s41598-025-23354-8

Products & Services: Protein Electrophoresis and Western

High Throughput Screening for SARS-CoV-2 Helicase Inhibitors

Authors: Yuka Otsuka; Eunjung Kim; Austin Krueger; Justin Shumate; Chao Wang; Bilel Bdiri; Sultan Ullah; HaJeung Park; Louis Scampavia; Thomas D. Bannister; Donghoon Chung; Timothy P. Spicer

Journal: SLAS discovery : advancing life sciences R & D

PubMed ID: 39173831

Doi: 10.1016/j.slasd.2024.100180