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A mutational atlas for Parkin proteostasis

Authors: Lene Clausen, Vasileios Voutsinos, Matteo Cagiada, Kristoffer E Johansson, Martin Grønbæk-Thygesen, Snehal Nariya, Rachel L Powell, Magnus K N Have, Vibe H Oestergaard, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

Journal: Nat Commun

PubMed ID: 38378758

Doi: 10.1038/s41467-024-45829-4

Products & Services: Mutagenesis Services

Constitutive activation mechanism of a class C GPCR

Authors: Jinwoo Shin, Junhyeon Park, Jieun Jeong, Jordy Homing Lam, Xingyu Qiu, Di Wu, Kuglae Kim, Joo-Youn Lee, Carol V Robinson, Jaekyung Hyun, Vsevolod Katritch, Kwang Pyo Kim, Yunje Cho

Journal: Nat Struct Mol Biol

PubMed ID: 38332368

Doi: 10.1038/s41594-024-01224-7

Products & Services: Protein and Antibody Isolation

Metabolic engineering of Synechocystis sp PCC 6803 for the improved production of phenylpropanoids

Authors: Kateryna Kukil, Pia Lindberg

Journal: Microb Cell Fact

PubMed ID: 38369470

Doi: 10.1186/s12934-024-02330-3

Products & Services: Codon Optimization

SPOP point mutations regulate substrate preference and affect its function

Authors: Yanran Deng, Wenhao Ding, Kaize Ma, Meixiao Zhan, Li Sun, Zizhang Zhou, Ligong Lu

Journal: Cell Death Dis

PubMed ID: 38409107

Doi: 10.1038/s41419-024-06565-1

Products & Services: Catalog Peptides

Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection

Authors: Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert Harmel, Phil Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres

Journal: RSC Med Chem

PubMed ID: 38665834

Doi: 10.1039/d3md00724c

Products & Services: Protein and Antibody Isolation

Cystatin from the helminth upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells

Authors: Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R Williams, Luis Caraballo

Journal: Front Immunol

PubMed ID: 38481989

Doi: 10.3389/fimmu.2024.1328401

Products & Services: Molecular Biology Reagents

Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from

Authors: Davide Doni, Eva Cavallari, Martin Ezequiel Noguera, Hernan Gustavo Gentili, Federica Cavion, Gustavo Parisi, Maria Silvina Fornasari, Geppo Sartori, Javier Santos, Massimo Bellanda, Donatella Carbonera, Paola Costantini, Marco Bortolus

Journal: Int J Mol Sci

PubMed ID: 38339189

Doi: 10.3390/ijms25031912

Products & Services: Molecular Biology Reagents

Antibodies toward Na,HCO-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer

Authors: Trine V Axelsen, Claus Olesen, Danish Khan, Ali Mohammadi, Elena V Bouzinova, Christine J F Nielsen, Marco Mele, Katrine R Hauerslev, Helene L Pedersen, Eva Balling, Pernille Vahl, Trine Tramm, Peer M Christiansen, Ebbe Boedtkjer

Journal: Br J Cancer

PubMed ID: 38310186

Doi: 10.1038/s41416-024-02591-0

Products & Services: Catalog Antibodies

Biomimetic bacteria-derived nanoclusters enhance ferroptosis cancer immunotherapy through synergistic CRISPR-photothermo modulation

Authors: Xiuhua Pan , Jie Yang , Ruixin Kang , Jun Zhang , Zongwei Hu , Ning Yang , Zengyi Liu , Zengguang Jia , Xiawei Zhou , Qi Shen

Journal: Nano Today

Doi: 10.1016/j.nantod.2024.102213

Products & Services: CRISPR Services

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Authors: Bipin Rimal, Stephanie L Collins, Ceylan E Tanes, Edson R Rocha, Megan A Granda, Sumeet Solanki, Nushrat J Hoque, Emily C Gentry, Imhoi Koo, Erin R Reilly, Fuhua Hao, Devendra Paudel, Vishal Singh 11, Tingting Yan 12, Min Soo Kim 2, Kyle Bittinger 3, Joseph P Zackular 13 14, Kristopher W Krausz 12, Dhimant Desai 15, Shantu Amin 15, James P Coleman 4, Yatrik M Shah 5, Jordan E Bisanz 2 16, Frank J Gonzalez 12, John P Vanden Heuvel 1 17, Gary D Wu 18, Babette S Zemel 3, Pieter C Dorrestein 7 8, Emily E Weinert 2 6, Andrew D Patterson 19 20 21

Journal: Nature

PubMed ID: 38326609

Doi: 10.1038/s41586-023-06990-w

Products & Services: Gene Synthesis