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A mutational atlas for Parkin proteostasis

Authors: Lene Clausen, Vasileios Voutsinos, Matteo Cagiada, Kristoffer E Johansson, Martin Grønbæk-Thygesen, Snehal Nariya, Rachel L Powell, Magnus K N Have, Vibe H Oestergaard, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

Journal: Nat Commun

PubMed ID: 38378758

Doi: 10.1038/s41467-024-45829-4

Products & Services: Mutagenesis Services

Constitutive activation mechanism of a class C GPCR

Authors: Jinwoo Shin, Junhyeon Park, Jieun Jeong, Jordy Homing Lam, Xingyu Qiu, Di Wu, Kuglae Kim, Joo-Youn Lee, Carol V Robinson, Jaekyung Hyun, Vsevolod Katritch, Kwang Pyo Kim, Yunje Cho

Journal: Nat Struct Mol Biol

PubMed ID: 38332368

Doi: 10.1038/s41594-024-01224-7

Products & Services: Protein and Antibody Isolation

Metabolic engineering of Synechocystis sp PCC 6803 for the improved production of phenylpropanoids

Authors: Kateryna Kukil, Pia Lindberg

Journal: Microb Cell Fact

PubMed ID: 38369470

Doi: 10.1186/s12934-024-02330-3

Products & Services: Codon Optimization

SPOP point mutations regulate substrate preference and affect its function

Authors: Yanran Deng, Wenhao Ding, Kaize Ma, Meixiao Zhan, Li Sun, Zizhang Zhou, Ligong Lu

Journal: Cell Death Dis

PubMed ID: 38409107

Doi: 10.1038/s41419-024-06565-1

Products & Services: Catalog Peptides

Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection

Authors: Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert Harmel, Phil Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres

Journal: RSC Med Chem

PubMed ID: 38665834

Doi: 10.1039/d3md00724c

Products & Services: Protein and Antibody Isolation

Cystatin from the helminth upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells

Authors: Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R Williams, Luis Caraballo

Journal: Front Immunol

PubMed ID: 38481989

Doi: 10.3389/fimmu.2024.1328401

Products & Services: Molecular Biology Reagents

Antibodies toward Na,HCO-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer

Authors: Trine V Axelsen, Claus Olesen, Danish Khan, Ali Mohammadi, Elena V Bouzinova, Christine J F Nielsen, Marco Mele, Katrine R Hauerslev, Helene L Pedersen, Eva Balling, Pernille Vahl, Trine Tramm, Peer M Christiansen, Ebbe Boedtkjer

Journal: Br J Cancer

PubMed ID: 38310186

Doi: 10.1038/s41416-024-02591-0

Products & Services: Catalog Antibodies

Conservation of Affinity Rather Than Sequence Underlies a Dynamic Evolution of the Motif-Mediated p53/MDM2 Interaction in Ray-Finned Fishes

Authors: Filip Mihalič, Dahiana Arcila, Mats E Pettersson, Pouria Farkhondehkish, Eva Andersson, Leif Andersson, Ricardo Betancur-R, Per Jemth

Journal: Mol Biol Evol

PubMed ID: 38301272

Doi: 10.1093/molbev/msae018

Products & Services: Protein and Antibody Isolation

Human sequences form R-loop structures

Authors: Agata M Parsons, Kemin Su, Maya Daniels, Gerrit J Bouma, Gregory B Vanden Heuvel, Erik D Larson

Journal: MicroPubl Biol

PubMed ID: 38371318

Doi: 10.17912/micropub.biology.001058

Products & Services: Gene Synthesis

Tandem repeats of highly bioluminescent NanoLuc are refolded noncanonically by the Hsp70 machinery

Authors: Dimitra Apostolidou, Pan Zhang, Devanshi Pandya, Kaden Bock, Qinglian Liu, Weitao Yang, Piotr E Marszalek

Journal: Protein Sci

PubMed ID: 38284490

Doi: 10.1002/pro.4895

Products & Services: Custom Vector Construction