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Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection

Authors: Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert Harmel, Phil Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres

Journal: RSC Med Chem

PubMed ID: 38665834

Doi: 10.1039/d3md00724c

Products & Services: Protein and Antibody Isolation

Cystatin from the helminth upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells

Authors: Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R Williams, Luis Caraballo

Journal: Front Immunol

PubMed ID: 38481989

Doi: 10.3389/fimmu.2024.1328401

Products & Services: Molecular Biology Reagents

Antibodies toward Na,HCO-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer

Authors: Trine V Axelsen, Claus Olesen, Danish Khan, Ali Mohammadi, Elena V Bouzinova, Christine J F Nielsen, Marco Mele, Katrine R Hauerslev, Helene L Pedersen, Eva Balling, Pernille Vahl, Trine Tramm, Peer M Christiansen, Ebbe Boedtkjer

Journal: Br J Cancer

PubMed ID: 38310186

Doi: 10.1038/s41416-024-02591-0

Products & Services: Catalog Antibodies

Conservation of Affinity Rather Than Sequence Underlies a Dynamic Evolution of the Motif-Mediated p53/MDM2 Interaction in Ray-Finned Fishes

Authors: Filip Mihalič, Dahiana Arcila, Mats E Pettersson, Pouria Farkhondehkish, Eva Andersson, Leif Andersson, Ricardo Betancur-R, Per Jemth

Journal: Mol Biol Evol

PubMed ID: 38301272

Doi: 10.1093/molbev/msae018

Products & Services: Protein and Antibody Isolation

Human sequences form R-loop structures

Authors: Agata M Parsons, Kemin Su, Maya Daniels, Gerrit J Bouma, Gregory B Vanden Heuvel, Erik D Larson