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Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses

Authors: Diana Castaño, Emily Bettini, Binod Kumar, Aleksey Chudnovskiy, Anna Siv, Giulia Protti, Sandra Nakadakari-Higa, Simona Ceglia, Nina De Luna, Joy E Chiu, Katlyn Lederer, Shuk Hang Li, Hassaan Ibrahim, Hiromi Muramatsu, Thandiswa Mdluli, Edit Abraham, Sinem E Sahingur, Ivan Maillard, Ying K Tam, Sunny Shin, Scott E Hensley, Jonathan J Miner, Zoltan Lipinszki, Andrea Reboldi, Norbert Pardi, Roberto Spreafico, Gabriel D Victora, Michela Locci

Journal: Cell

PubMed ID: 41406961

Doi: 10.1016/j.cell.2025.11.023

The resting and ligand-bound states of the membrane-embedded human T-cell receptor–CD3 complex

Authors: Ryan Q Notti, Fei Yi, Søren Heissel, Martin W Bush, Zaki Molvi, Pujita Das, Henrik Molina, Christopher A Klebanoff, Thomas Walz

Journal: Nature Communications

PubMed ID: 41402338

Doi: 10.1038/s41467-025-66939-7

A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions

Authors: Mebratu A Bitew, Tatiana C Paredes-Santos, Parag Maru, Shruthi Krishnamurthy, Yifan Wang, Lamba O Sangaré, Samuel Duley, Yoshiki Yamaryo-Botté, Cyrille Y Botté, Jeroen P J Saeij

Journal: Nature Communications

PubMed ID: 41407671

Doi: 10.1038/s41467-025-66137-5

Products & Services: Protein and Antibody Isolation

Engineered ipilimumab variants that bind human and mouse CTLA-4

Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee

Journal: MAbs

PubMed ID: 39849917

Doi: 10.1080/19420862.2025.2451296

Products & Services: Combinatorial Mutant library

The prion-like characteristic of ORF3 contributes to virion release and pathogenesis of hepatitis E virus

Authors: Yajing Wang, Houlu Tian, Na Shi, Chunyan Wu, Yaowei Huang, Yongling Yang, Qiang Ding, Xu Zheng, Qin Zhao, Zhaonong Hu, Jiaojiao Luo, Lele Feng, Lingdong Xu, Mick F Tuite, Hongying Chen, Yuchen Nan

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41343667

Doi: 10.1073/pnas.2511801122

Products & Services: Polyclonal Antibody Services

Targeting SKAP2 restores sperm motility and morphology through modulating mitochondrial organization and cytoskeletal remodeling

Authors: Shiming Gan, Lin Yin, Jiaming Zhou, Sisi Li, Shumin Zhou, Xiaotong Yang, Rui Liu, Xu Fan, Yangyang Li, Zhendong Yao, Jingshou Chen, Peiran Hu, Wenjing Xiong, Yuan Yuan, Yujiao Wen, Youjiang Li, Ge Jin, Jianzhong Sheng, Yuzhen Gao, Hefeng Huang, Chen Zhang

Journal: Signal transduction and targeted therapy

PubMed ID: 41436426

Doi: 10.1038/s41392-025-02513-3

Products & Services: Protein and Antibody Isolation

Natural variation in OsTPS8 confers differential regulation of chalkiness and seed vigor in indica and japonica rice

Authors: Xiaoli Chen, Yulong Ren, Hui Dong, Xiaokang Jiang, Xiaoming Zheng, Erchao Duan, Xuan Teng, Yunlong Wang, Chuanwei Gu, Rongbo Chen, Qingkai Wang, Yongfei Wang, Yipeng Zhang, Rushuang Zhang, Yunpeng Zhang, Wenjie Zhao, Yu Zhang, Xue Yang, Lei Zhou, Chao Li, Tiaofeng Shan, Yiqun Bao, Yunlu Tian, Xi Liu, Shijia Liu, Tao Guo, Mingjiang Chen, Haiyang Wang, Yihua Wang, Jianmin Wan

Journal: Nature Genetics

PubMed ID: 41398376

Doi: 10.1038/s41588-025-02429-2

Products & Services: Protein Electrophoresis and Western Recombinant Proteins

Efficient high-precision transgene knock-in by Recombinases (Redα/β)-enhanced DNA integration-CRISPR-Cas9 (RED-CRISPR)

Authors: Wenqing Li, Senquan Liu, Xiaoyu Fang, Jiaqi Zou, Qin Jiang, Xiaolin Min, Xiaoli Zhu, Yuzhu Cao, Xiaoxiao Gao, Wenjie Han, Muhammad Azhar, Xuemei Xing, Fudong Li, Youming Zhang, Hongbin Liu, Linzhao Cheng, Chengkun Wang, Jianqiang Bao

Journal: Nature Communications

PubMed ID: 41365890

Doi: 10.1038/s41467-025-67239-w

Products & Services: Catalog IVT RNA products

Structural insights into kainate receptor desensitization

Authors: Changping Zhou, Guadalupe Segura-Covarrubias, Nami Tajima

Journal: Nature Communications

PubMed ID: 41365859

Doi: 10.1038/s41467-025-65920-8

Gene-corrected regulatory T cell therapy for IL2RA deficiency

Authors: Alvin S Ha, Nechama Kalter, Michael Rosenberg, Luis A Acevedo, Brianna Liang, Weihong Liu, Sreenivasan Paruthiyil, Meenal Sinha, Alexander Vu, Vinh Nguyen, Zhongxia Qi, Netravathi Krishnappa, Jinna Shu, Jingwei Yu, Jason Catanzaro, Jeffrey A Bluestone, Qizhi Tang, Fyodor D Urnov, Alexander Marson, Ayal Hendel, Kevan C Herold, Brian R Shy, Jonathan H Esensten

Journal: Molecular Therapy

PubMed ID: 41376159

Doi: 10.1016/j.ymthe.2025.12.004

Products & Services: Molecular Biology Reagents