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Gene Synthesis> | … no. 9202) were purchased from Cell Signaling Technology, Inc. (Danvers, MA, USA). The C terminal FLAG-tagged LAIR1 inserted into pcDNA3.1 (pcDNA3.1/LAIR1-FLAG) was purchased from GenScript Biotech Corp. (Township, NJ, USA). Clinical specimens … | Get A Quote |
Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, responsible for approximately 90‑95% of cases. We previously reported a novel method that enables direct extraction of extracellular vesicles (EVs) from surgically resected viable tissues, yielding what we term tissue‑exudative extracellular vesicles (Te‑EVs). Quantitative LC/MS analysis identified 3,871 proteins in Te‑EVs, among which leukocyte‑associated immunoglobulin‑like receptor 1 (LAIR1) was highly enriched in tumor Te‑EVs. In the present study, we found that LAIR1 was significantly upregulated in clinical specimens of human RCC tumor tissues compared to that noted in adjacent non‑cancerous renal tiss... More