资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

Synthesis and preclinical characterization of [64Cu]NODAGA-MAL-exendin-4 with a Nε-maleoyl-L-lysyl-glycine linkage.

Nucl. Med. Biol.. 2013;

YimCheng-Bin，MikkolaKirsi，FagerholmVeronica，ElomaaViki-Veikko，IshizuTamiko，RajanderJohan，SchlesingerJoern，RoivainenAnne，NuutilaPirjo，Solin

Products/Services Used	Details	Operation
Proteins, Expression, Isolation and Analysis	… NODAGA-tris( t Bu) (4-(4,7-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7-triazacyclononan-1-yl)- 5-(tert-butoxy)-5-oxopentanoic acid) was purchased from CheMatech (Dijon, France). [ 40 Cys]exendin-4(1-39) was purchased from GenScript USA Inc …	Get A Quote

摘要

Renal localization of high radioactivity levels during targeted imaging compromises tissue visualization in the kidney region and limits diagnostic accuracy. Radioiodinated antibody fragments with a renal enzyme-cleavable N(ε)-maleoyl-L-lysyl-glycine (MAL) linkage demonstrated low renal radioactivity levels in mice， from early postinjection times. This study tested the hypothesis whether a (64)Cu-labeled NODAGA-exendin-4 peptide with a MAL linkage ([(64)Cu]NODAGA-MAL-exendin-4) could decrease kidney radioactivity levels in rats， compared to a [(64)Cu]NODAGA-exendin-4 reference， without impairing the radioactivity levels in the target tissue.