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Intracerebroventricular administration of lupus serum induces microglia activation and leukocyte adhesion in the cerebromicrovasculature of mice.

J. Neuroimmunol.. 2019;

WangXuejiao，LiYingzhuo，WangYuchen，FengQianhui，YangPingting，Qin

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Proteins, Expression, Isolation and Analysis	For in vitro experiments, IgG was iso- lated from the pooled patient or normal serum using a protein A-resin (genScript, Piscataway, NY) and concentrated using Amicon Ultra Centrifugal Filter Units (Millipore, Billerica, MA).	Get A Quote

摘要

Central nervous system (CNS) involvement is commonly seen in the patients with system lupus erythematosus (SLE). Mechanisms underlying CNS damage in SLE remain largely unknown. Accumulating evidence suggest that activation of microglia in CNS plays an important role in the inflammatory responses in neurological diseases. The aim of this study is to examine the involvement of microglia in the CNS inflammatory responses induced by circulating serum of SLE patients.