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WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1.

Mol. Cancer. 2019;

ChenYunhao，PengChuanhui，ChenJunru，ChenDiyu，YangBeng，HeBin，HuWendi，ZhangYanpeng，LiuHua，DaiLongfei，XieHaiyang，ZhouLin，WuJian，ZhengSh

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Proteins, Expression, Isolation and Analysis	An equal amount of protein samples was separated by 4–12% SDS-PAGE (GenScript, Nanjing, China) and then transferred to 0.45 μm PVDF membranes (Millipore, USA).	Get A Quote

摘要

N6-methyladenosine (m6A) methylation， a well-known modification with new epigenetic functions， has been reported to participate in the tumorigenesis of hepatocellular carcinoma (HCC)， providing novel insights into the molecular pathogenesis of this disease. However， as the key component of m6A methylation， Wilms tumor 1-associated protein (WTAP) has not been well studied in HCC. Here we investigated the biological role and underlying mechanism of WTAP in liver cancer.