Products/Services Used | Details | Operation |
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Peptide Synthesis> | Peptide SWLAYPGAVSYRGNCC (tether-MAP) was custom synthesized by GenScript (>95% purity), provided in small aliquots and stored at 20 C to reduce freeze/thaw cycles of the peptide. | Get A Quote |
The mechanism of matrix metalloproteinase-8 (MMP-8) inhibition was investigated using ellipsometric measurements of the interaction of MMP-8 with a surface bound peptide inhibitor, tether-metal abstraction peptide (MAP), bound to self-assembled monolayer films. MMP-8 is a collagenase whose activity and dysregulation have been implicated in a number of disease states, including cancer metastasis, diabetic neuropathy, and degradation of biomedical reconstructions, including dental restorations. Regulation of activity of MMP-8 and other matrix metalloproteinases is thus a significant, but challenging, therapeutic target. Strong inhibition of MMP-8 activity has recently been achieved via the small metal binding pep... More