Products/Services Used | Details | Operation |
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Proteins, Expression, Isolation and Analysis> | … The cPass Neutralization Antibody Detection kit (GenScript) was used to detect circulating neutralizing antibodies against SARS-CoV-2 that block the interaction between the RBD of the viral spike glycoprotein with the angiotensin-converting enzyme 2 (ACE2) cell surface … | Get A Quote |
background: Vaccine-induced neutralizing antibodies are key in combating the COVID-19 pandemic. However, delays of boost immunization due to limited availability of vaccines may leave individuals vulnerable to infection and prolonged or severe disease courses. The emergence of SARS-CoV-2 variants of concern (VOC), B.1.1.7 (United Kingdom), B.1.351 (South Africa), and P.1 (Brazil), may exacerbate this issue, as the latter two are able to evade control by antibodies. methods: We assessed humoral and T cell responses against SARS-CoV-2 WT, VOC and endemic human coronaviruses (hCoV) that were induced after single and double vaccination with BNT162b2. results: Despite readily detectable IgG against the receptor-bind... More