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Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021

Euro Surveill. 2022-01;

Shirley Ll Kwok, Samuel Ms Cheng, Jennifer Ns Leung, Kathy Leung, Cheuk-Kwong Lee, Js Malik Peiris, Joseph T Wu

Products/Services Used	Details	Operation
Proteins, Expression, Isolation and Analysis	… the ELISA cut-off is 0.5 optical density (OD) [2]. Samples were further tested using a surrogate virus neutralisation test (sVNT) kit (GenScript, New Jersey, United States), which measures …	Get A Quote

摘要

The mRNA vaccine Comirnaty and the inactivated vaccine CoronaVac are both available in Hong Kong's COVID-19 vaccination programme. We observed waning antibody levels in 850 fully vaccinated (at least 14 days passed after second dose) blood donors using ELISA and surrogate virus neutralisation test. The Comirnaty-vaccinated group's (n = 593) antibody levels remained over the ELISA and sVNT positive cut-offs within the first 6 months. The CoronaVac-vaccinated group's (n = 257) median antibody levels began to fall below the cut-offs 4 months after vaccination.