CHO-K1/CysLT1/Gα15 Stable Cell Line

CysLT1 (Cysteinyl leukotriene receptor 1) is previous named as LTD4 receptor (leukotriene D4 receptor). It is a receptor for cysteinyl leukotrienes and has highest affinity to leukotriene D4 (LTD4). The receptor mediates contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung caused by LTD4. A CysLT1 selective antagonist, montelukast, is used clinically in the treatment of asthma.. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

产品编号	M00462
规格	2 vials 大单询价
数量
价格	询价


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Synonyms

CysLT1 receptor, LTD4, HG55, HMTMF81, LTD4, CysLT1, CYSLT1R, cysteinyl leukotriene receptor 1, leukotriene D4 receptor, BB147369

产品概述

Applications

Functional assay for CysLT1 receptor

产品简介

Storage	Liquid nitrogen immediately upon delivery
Species	Human

培养条件

Freeze Medium	45% culture medium, 45% FBS (Cat. #10099-141, Gibco), 10% DMSO (Cat. #D2650, Sigma)
Culture Medium	Ham’s F-12K (Kaighn’s), 10% FBS, 400 μg/ml Geneticin (Cat. #10131-035, Life Technologies), 100 μg/ml Hygromycin B (Cat. #10687010, Invitrogen)