目录产品 » Cyno Recombinant TIGIT Stable Cell Line
CHO-K1/cyno TIGIT Stable Cell Line

FACS analysis of Cyno TIGIT expression in CHO-K1 cells.

CHO-K1/cyno TIGIT Stable Cell Line

FACS analysis of Cyno TIGIT expression in CHO-K1 cells.

CHO-K1/cyno TIGIT Stable Cell Line

FACS analysis of Cyno TIGIT expression in CHO-K1 cells.

CHO-K1/cyno TIGIT Stable Cell Line

TIGIT (T cell immunoreceptor with Ig and ITIM domains) was recently characterized as an inhibitory receptor, which is expressed mainly on NK, Treg, CD8+ T, and CD4+ T cells. TIGIT harbors an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif and an ITIM (immunoreceptor tyrosine-based inhibition motif) in its cytoplasmic tail. The poliovirus receptor (PVR or CD155) was identified as the physical ligand of TIGIT with high affinity, and PVRL2 (Nectin2 or CD112) also binds to TIGIT with a weaker binding capacity. TIGIT/PVR engagement suppresses T cell activation through IL-10 secretion mediated by dendritic cells. Furthermore, TIGIT also exerts an intrinsic inhibitory function to T cell activation.
M00672
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Description

TIGIT (T cell immunoreceptor with Ig and ITIM domains) was recently characterized as an inhibitory receptor, which is expressed mainly on NK, Treg, CD8+ T, and CD4+ T cells. TIGIT harbors an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif and an ITIM (immunoreceptor tyrosine-based inhibition motif) in its cytoplasmic tail. The poliovirus receptor (PVR or CD155) was identified as the physical ligand of TIGIT with high affinity, and PVRL2 (Nectin2 or CD112) also binds to TIGIT with a weaker binding capacity. TIGIT/PVR engagement suppresses T cell activation through IL-10 secretion mediated by dendritic cells. Furthermore, TIGIT also exerts an intrinsic inhibitory function to T cell activation.

Applications Binding assay or use as immunogen

Storage Liquid nitrogen immediately upon receiving
Species Cyno
Stability 15 passages

Freeze Medium 95% complete growth medium, 5% DMSO
Culture Medium F12K, 10% FBS, 8 μg/ml Puromycin

  • CHO-K1/cyno TIGIT Stable Cell Line
  • CHO-K1/cyno TIGIT Stable Cell Line

    FACS analysis of Cyno TIGIT expression in CHO-K1 cells.

  • CHO-K1/cyno TIGIT Stable Cell Line
  • CHO-K1/cyno TIGIT Stable Cell Line

    FACS analysis of Cyno TIGIT expression in CHO-K1 cells.

  • CHO-K1/cyno TIGIT Stable Cell Line
  • CHO-K1/cyno TIGIT Stable Cell Line

    FACS analysis of Cyno TIGIT expression in CHO-K1 cells.


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