GenLNP-S03-EGFP mRNA (m1Ψ) - T cells Targeted

The GenLNP-S03-EGFP mRNA (m1Ψ) is a CD3 antibody decorated LNP loaded with eGFP mRNA (m1Ψ) displays anti-human CD3 antibody (OKT3) mAb, Mouse (GenScript, Cat: A02199) to enhance its targeting efficiency to CD3 positive cells. The antibody is covalently conjugated to lipid molecule for achieving targeting effect. The LNP is formulated with main ionizable lipid of SM102. The payload eGFP mRNA (m1Ψ) has all the U bases 100% modified with N1-methyl-pseudo-Uridine. This LNP formulation showed enhanced delivery of eGFP mRNA to CD3+ T cells.