GenLNP-S04-EGFP mRNA (m1Ψ) - CD34+ Cells Targeted

The GenLNP-S04-EGFP mRNA (m1Ψ) is a CD34 antibody decorated LNP loaded with eGFP mRNA (m1Ψ). It displays anti-human CD34 antibody mAb, Mouse (GenScript, Cat: CP0001) to enhance its targeting efficiency to CD34 positive cells. The antibody is covalently conjugated to lipid molecule for achieving targeting effect. The LNP is formulated with main ionizable lipid of SM102. The payload eGFP mRNA (m1Ψ) has all the U bases 100% modified with N1-methyl-pseudo-Uridine. This LNP formulation showed enhanced delivery of eGFP mRNA to CD34+ stem cells.