GenLNP-S05-FLuc mRNA (m1Ψ) - Liver Targeted

The GenLNP-S05-FLuc mRNA (m1Ψ) is a 5 component LNP loaded with Fluc mRNA (m1Ψ) has liver specific targeting effect after systemic administration. The LNP is formulated with main ionizable lipid of SM102 and Cationic lipid DODAP. The payload Fluc mRNA (m1Ψ) has all the U bases 100% modified with N1-methyl-pseudo-Uridine. This LNP formulation showed enhanced delivery of liver tissue in vivo.