GenLNP-A02-Fluc mRNA (m1Ψ) - Lung Targeted

The GenLNP-A02-Fluc mRNA (m1Ψ) is a 3-component LNP loaded with Fluc mRNA (m1Ψ) has lung specific targeting effect after systemic administration. The LNP is formulated with 3 lipid components and the main ionizable lipid is ALC0315. The payload Fluc mRNA (m1Ψ) has all the U bases 100% modified with N1-methyl-pseudo-Uridine. This LNP formulation showed enhanced delivery of lung tissue after in vivo delivery.