GenLNP-S06-FLuc mRNA (m1Ψ) - Spleen Targeted

The GenLNP-S06-FLuc mRNA (m1Ψ) is a LNP loaded with Fluc mRNA (m1Ψ) has spleen specific targeting effect after systemic administration. The LNP is formulated with main ionizable lipid of SM102 and cationic lipid 18PA. The payload Fluc mRNA (m1Ψ) has all the U bases 100% modified with N1-methyl-pseudo-Uridine. This LNP formulation showed enhanced delivery of spleen organ after in vivo delivery.