![LIF, Mouse LIF, Mouse](/product/documents/down?doc_name=Z03077_cell Differentiation Assay.png&file=scm_files/productFile_notes/2024/01/19/2f3aaa02-8b92-4692-b705-d8ccf26e1c8f.png)
ED50 < 0.01 ng/ml, measured by a cell differentiation assay using M1 cells, corresponding to a specific activity of > 1.0 × 108 units/mg.
![LIF, Mouse LIF, Mouse](/product/documents/down?doc_name=Z03077_SDS-PAGE.png&file=scm_files/productFile_notes/2024/01/19/3ab15989-777b-48f4-bd46-647878ca7d63.png)
Lane 1: 2 μg of LIF, Mouse, reducing (R)
Lane 2: 2 μg of LIF, Mouse, non-reducing (NR)
> 95% as analyzed by SDS-PAGE
LIF, Mouse
Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine belonging to the long four-helix bundle cytokine superfamily. LIF shares tertiary structure with several other cytokines, including Interleukin-6 (IL-6), Oncostatin M, ciliary neurotropic factor, and cardiotrophin-1, and their functions in vivo are also redundant to some extent. LIF can bind to the common receptor of IL-6 subfamily, gp130, and then recruit its own receptor LIF Receptor to form a ternary complex. The basal expression of LIF in vivo is low; and its expression is induced by pro-inflammatory factors, including lipopolysaccharide, IL-1, and IL-17, and inhibited by anti-inflammatory agents, including IL-4 and IL-13. The functions of LIF include proliferation of primordial germ cells, regulation in blastocyst implantation and early pregnancy, and maintenance of pluripotent embryonic stem cells.
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