![CD38, Human CD38, Human](/product/documents/down?doc_name=Z03394_activity.jpg&file=scm_files/productFile_notes/2021/05/24/a3b3fa53-dc68-4e69-9c86-f1a004346576.jpg)
CD38, Human at 1 μg/ml (100 μl/well) can bind Human CD38 Antibody (38.F2), Mouse with EC50=1.640 ng/ml when detected by M6 Goat Anti Mouse (Fc). Background was subtracted from data points before curve fitting.
CD38, Human
CD38 (also referred to as T10 antigen) is a nonlineage-restricted type II transmembrane glycoprotein that has emerged as an intracellular calcium ion mobilizing messenger. It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose. The enzymatic functions of CD38 probably contribute to an array of its immunoregulatory functions. It has been found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. Soluble CD38 and the ability of membrane-bound CD38 to become internalized in response to appropriate stimuli suggest that extracellular and intracellular roles for this protein are equally plausible.
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