| Species |
Cynomolgus |
| Protein Construction |
GUCY2C/Guanylyl cyclase C (Ser24-Gln430)
Accession # XP_005570270.1 |
His |
| N-term |
C-term |
|
| Purity |
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC |
| Endotoxin Level |
Less than 1EU per μg by the LAL method. |
| Biological Activity |
Immobilized GUCY2C/Guanylyl cyclase C, His, Cynomolgus (Cat.No.: Z03914) at 5 μg/ml (100μl/Well) on the plate can bind Anti-GUCY2C Antibody, hFc Tag |
| Expression System |
HEK293 |
| Theoretical Molecular Weight |
47.2 kDa |
| Apparent Molecular Weight |
Due to glycosylation, the protein migrates to 60-75 kDa based on Bis-Tris PAGE result. |
| Formulation |
Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4 . |
| Reconstitution |
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml. |
| Storage & Stability |
Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Immobilized GUCY2C/Guanylyl cyclase C, His, Cynomolgus at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GUCY2C Antibody, hFc Tag with the EC50 of 34.0 ng/ml determined by ELISA.
GUCY2C/Guanylyl cyclase C, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of GUCY2C/Guanylyl cyclase C, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.
| Target Background |
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. |
| Synonyms |
Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; GUC2CEC 4.6.1.2; MUCIL |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
